Abstract
The objective of this prospective study was to evaluate both thyroid function in children with Hashimoto’s thyroiditis and the necessity of lifetime thyroxine replacement therapy. A total of 47 patients with goiter and positive thyroid auto-antibodies participated in the study. Serum thyroxine and thyrotropin levels and titers of thyroid auto-antibodies were checked regularly throughout the follow-up period. At the beginning of the study, 25 patients were diagnosed as euthyroid, but at the end of the study, 22 patients initially diagnosed with euthyroidism remained euthyroid, while eight patients with subclinical hypothyroidism and three patients with overt hypothyroidism had become euthyroid. Thus, of the 22 patients with thyroid dysfunction at diagnosis, subclinical or overt, 11 became euthyroid during the follow-up period. The effect of thyroxine treatment on thyroid auto-antibody titers was not significant. Conclusion: Our data shows that Hashimoto’s thyroiditis in children has a benign course and that thyroid function in one half of the patients with thyroid dysfunction at diagnosis reverts to normal. Careful follow-up of thyroid function is important in order to determine the necessity and timing of thyroxine replacement therapy.
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Abbreviations
- AMA:
-
Anti-microsomal antibody
- ATA:
-
Anti-thyroglobulin antibody
- T4:
-
Thyroxine
- TSH:
-
Thyrotropin
References
Gruneiro de Papendieck L, Iorcansky S, Rivarola MA, Bergadá C (1982) Variations in clinical, hormonal and serological expressions of chronic lymphocytic thyroiditis (CLT) in children and adolescents. Clin Endocrinol 16:19–28
Hegedüs L, Hansen JM, Feldt-Rasmussen U, Hansen BM, Høier-Madsen M (1991) Influence of thyroxine treatment on thyroid size and anti-thyroid peroxidase antibodies in Hashimoto’s thyroiditis. Clin Endocrinol 35:235–238
Jaruratanasirikul S, Leethanaporn K, Khuntigij P, Sriplung H (2001) The clinical course of Hashimoto’s thryoiditis in children and adolescents: 6 years longitudinal follow-up. J Pediatr Endocrinol Metab 14:177–184
Leboeuf G, Ducharme JR (1966) Thyroiditis in children. Diagnosis and management. Pediatr Clin North Am 13:19–42
Mäenpää J, Raatikka M, Räsänen J, Taskinen E, Wager O (1985) Natural course of juvenile autoimmune thyroiditis. J Pediatr 107:898–904
Moore DC (1996) Natural course of ‘subclinical’ hypothyroidism in childhood and adolescence. Arch Pediatr Adolesc Med 150:293–297
Nikolai TF (1989) Recovery of thyroid function in primary hypothyroidism. Am J Med Sci 297:18–21
Padberg S, Heller K, Usadel KH, Schumm-Draeger PM (2001) One-year prophylactic treatment of euthyroid Hashimoto’s thyroidits patients with levothyroxine: is there a benefit? Thyroid 11:249–255
Papapetrou PD, Lazarus JH, MacSween RNM, Harden RM (1972) Long-term treatment of Hashimoto’s thyroiditis with thyroxine. Lancet 2:1045–1048
Rallison ML, Dobyns BM, Keating FR, Rall JE, Tyler FH (1975) Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr 86:675–682
Rallison ML, Dobyns BM, Meikle AW, Bishop M, Lyon JL, Stevens W (1991) Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults. Am J Med 91:363–370
Romaldini JH, Biancalana MM, Figueiredo DI, Farah CS, Mathias PC (1996) Effect of L-thyroxine administration on antithyroid antibody levels, lipid profile, and thyroid volume in patients with Hashimoto’s thyroiditis. Thyroid 6:183–188
Sklar CA, Qazi R, David R (1986) Juvenile autoimmune thyroiditis. Hormonal status at presentation and after long-term follow-up. Am J Dis Child 140:877–880
Takasu N, Yamada T, Takasu M, Komiya I, Nagasawa Y, Asawa T, Shinoda T, Aizawa T, Koizumi Y (1992) Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis. N Engl J Med 326:513–518
Vanderpump MPJ, Tunbridge WMG, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Hasan DM, Rodgers H, Tunbridge F, Young ET (1995) The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 43:55–68
Yamamoto M, Kaise K, Kitaoka H, Yoshida K, Kaise N, Fukazawa H, Sakurada T, Saito S, Yoshinaga K (1983) Recovery of thyroid function with a decreased titre of antimicrosomal antibody in a hypothyroid man with Hashimoto’s thyroiditis. Acta Endocrinol 102:531–534
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Wang, SY., Tung, YC., Tsai, WY. et al. Long-term outcome of hormonal status in Taiwanese children with Hashimoto’s thyroiditis. Eur J Pediatr 165, 481–483 (2006). https://doi.org/10.1007/s00431-006-0112-5
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DOI: https://doi.org/10.1007/s00431-006-0112-5