Abstract
The urorectal septum malformation sequence (URSMS) consists of multiple systems anomalies including ambiguous genitalia, the absence of a perineal opening, an imperforate anus, and urogenital, colonic and lumbosacral anomalies. We describe a 3-day-old female infant with characteristic URSMS and review its clinical manifestations, outcomes and putative pathogenesis. We also compare its characteristics with those of the vertebral defects, anal atresia, tracheo-oesophageal fistula, renal defects and radial dysplasia (VATER) association. Conclusion:Although defects of the urorectal septum malformation sequence and the vertebral defects, anal atresia, tracheo-oesophageal fistula, renal defects and radial dysplasia association overlap, we believe that they are separate entities. Differentiating the urorectal septum malformation sequence from vertebral defects, anal atresia, tracheo-oesophageal fistula, renal defects and radial dysplasia association is helpful to develop appropriate clinical investigations and search for the aetiology and pathogenesis of these diseases.
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Abbreviations
- URSMS :
-
urorectal septum malformation sequence
- VATER :
-
vertebral defects, anal atresia, tracheo-oesophageal fistula, renal defects and radial dysplasia
References
Apold J, Dahl E, Aarskog D (1976) The Vater association: malformations of the male external genitalia. Acta Paediatr Scand 65: 150–152
Baumann W, Greinacher I, Emmerich P, Spranger J (1976) VATER or VACTERL Syndrom. Klin Pediatr 188: 328–337
Bohring A (2002) OEIS complex, VATER, and the ongoing difficulties in terminology and delineation. Am J Med Genet 107: 72–76
Botto LD, Khoury MJ, Mastroiacovo P, Castilla EE, Moore CA, Skjaerven R, Mutchinick OM, Borman B, Cocchi G, Czeizel AE, Goujard J, Irgens LM, Lancaster PA, Martinez-Frias ML, Merlob P, Ruusinen A, Stoll C, Sumiyoshi Y (1997) The spectrum of congenital anomalies of the VATER association: an international study. Am J Med Genet 71: 8–15
Cohen MM Jr, Rollnick BR, Kaye CI (1989) Oculoauriculovertebral spectrum: an updated critique. Cleft Palate J 26: 276-286
Cox H, Viljoen D, Versfeld G, Beighton P (1989) Radial ray defects and associated anomalies. Clin Genet 35: 322–330
Escobar LF, Weaver DD, Bixler D (1987) Urorectal septum malformation sequence. Report of six cases and embryological analysis. Am J Dis Child 141: 1021–1024
Fernbach SK, Glass RB, (1988) The expanded spectrum of limb anomalies in the VATER association. Pediatr Radiol 18: 215–220
Gilbert J, Clark RD, Koyle MA (1990) Penile agenesis: a fatal variation of an uncommon lesion. J Urol 143: 338–339
Gripp KW, Barr M Jr, Anadiotis G, McDonald-McGinn DM, Zderic SA, Zackai EH (1999) Aphallia as part of urorectal septum malformation sequence in an infant of a diabetic mother. Am J Med Genet 82: 363–367
Henmi N, Okubo S, Kasahara T, Okugawa T, Yamazaki H, Harada W, Uchiyama M (2000) A case of esophageal atresia with tracheoesophageal fistula, imperforate anus, persistent cloaca, incomplete fusion of the labium and chronic renal failure due to urethral obstruction. Pediatr Int 42: 585–588
Klinger G, Merlob P, Aloni D, Maayan A, Sirota L (1997) Normal pulmonary function in a monoamniotic twin discordant for bilateral renal agenesis: report and review. Am J Med Genet 73: 76–79
Kutiyanawala M, Wyse RK, Brereton RJ, Spitz L, Kiely EM, Drake D, Blake K (1992) CHARGE and esophageal atresia. J Pediatr Surg 27: 558–560
Major SG (1929) Persistence of the cloaca: report of case. Minnesota Med 12: 96–97
Orstavik KH, Steen-Johnsen J, Foerster A, Fjeld T, Skullerud K, Lie SO (1992) VACTERL or MURCS association in a girl with neurenteric cyst and identical thoracic malformations in the father: a case of gonosomal mosaicism? Am J Med Genet 43: 1035–1038
Pagon RA, Graham JM, Zonana J (1981) Coloboma, congenital heart disease, and choanal atresia with multiple anomalies: CHARGE association. J Pediatr 99: 223–227
Quan L, Smith DW (1973) The VATER association: vertebral defects, anal atresia, T-E fistula with esophageal atresia, radial and renal dysplasia: a spectrum of associated defects. J Pediatr 82: 104–107
Rabinowitz JG, Pelzman H, Robinson T (1971) Small pelvic outlet associated with underdevelopment of the urinary tract and other anomalies. Radiology 101: 629–630
Russell LJ, Weaver DD, Bull MJ (1981) The axial mesodermal dysplasia spectrum. Pediatrics 67: 176–182
Say B (1975) Misuse of acronyms and the VATER association. J Pediatr 86: 315
Sofatzis JA, Alexacos L, Skouteli HN, Tiniakos G, Padiatellis C (1983) Malformed female genitalia in newborns with the VATER association. Acta Paediatr Scand 72: 923–924
Weaver DD, Mapstone CL, Yu P (1986) The VATER association. Analysis of 46 patients. Am J Dis Child 140: 225–229
Wenstrup RJ, Pagon RA (1985) Female pseudohermaphroditism with anorectal, mullerian duct, and urinary tract malformations: report of four cases. J Pediatr 107: 751–754
Wheeler PG, Weaver DD (2001) Partial urorectal septum malformation sequence: a report of 25 cases. Am J Med Genet 103: 99-105
Wheeler PG, Weaver DD, Obeime MO, Vance GH, Escobar LF (1997) Urorectal septum malformation sequence: report of thirteen additional cases and review of the literature. Am J Med Genet 73: 456–462
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Chien, JC., Chen, SJ., Tiu, CM. et al. Is urorectal septum malformation sequence a variant of the vertebral defects, anal atresia, tracheo-oesophageal fistula, renal defects and radial dysplasia association? Report of a case and a review of the literature. Eur J Pediatr 164, 350–354 (2005). https://doi.org/10.1007/s00431-005-1630-2
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DOI: https://doi.org/10.1007/s00431-005-1630-2