Skip to main content

Advertisement

Log in

Juvenile sarcoidosis presenting as Crohn’s Disease

  • Original Paper
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

A 12-year-old Turkish girl suffered from abdominal pain located in the right lower abdomen for 3 weeks. Ultrasound revealed palisade-like swelling of the mucosa in the ileum. Gastrointestinal biopsy showed incipient granulomas in the stomach and moderate fibrosis of the terminal ileum. Subsequently, bilateral hilar adenopathy and an abnormal level of serum angiotensin-converting enzyme were detected. The relevance of paediatric sarcoidosis mimicking Crohn’s disease is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Abbreviations

ACE:

Angiotensin-converting enzyme

CD:

Crohn’s disease

CRP:

C-reactive protein

EOS:

Early-onset sarcoidosis

ESR:

Erythrocyte sedimentatioln rate

References

  1. Al Binali AM, Brent S, Al-Garni A, Montgomery M, Robertson M (2003) Granulomatous pulmonary disease in a child: an unusual presentation of Crohn’s disease. Pediatr Pulmonol 36:76–80

    Article  PubMed  Google Scholar 

  2. Calder CJ, Lacy D, Raafat F, Weller PH, Booth IW (1993) Crohn’s disease with pulmonary involvement in a 3-year-old child. Gut 34:1636–1638

    Article  PubMed  CAS  Google Scholar 

  3. Dumot JA, Adal K, Petras RE, Lashner B (1988) Am J Gastroenterol 93:1949–1951

    Article  Google Scholar 

  4. Dunbar RD (1978) Sarcoidosis and its radiologic manifestations. CRC Crit Rev Diagn Imaging 11(2):185–221

    PubMed  CAS  Google Scholar 

  5. Fries W, Grassi SA, Leone L, Giacomin D, Galeazzi F, Naccarato R, Martin A (1995) Association between inflammatory bowel disease and sarcoidosis. Scand J Gastroenterol 30:1221–1223

    Article  PubMed  CAS  Google Scholar 

  6. Hunt SJ, Wakelin SH, Walters S, O’Toole E, Philips W, Hardman C (2002) A case of childhood sarcoidosis. Clin Exp Dermatol 27: 448–450

    Article  PubMed  CAS  Google Scholar 

  7. Hyams JS (1994) Extraintestinal manifestations of inflammatory bowel disease in children. J Pediatr Gastroenterol Nutr 19:7–21

    Article  PubMed  CAS  Google Scholar 

  8. Inohara N, Nunez G (2003) NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3:371–82

    Article  PubMed  CAS  Google Scholar 

  9. Kanazawa N, Okafuji I, Kambe N, Nishikomori R, Nakata-Hizume M, Nagai S, Fuji A, Yuasa T, Manki A, Sakurai Y, Nakajima M, Kobayashi H, Fujiwara I, Tsutsumi H, Utani A, Nishigori C, Heike T, Nakahata T, Miyachi Y (2005) Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. Blood 105:1195–1197

    Article  PubMed  CAS  Google Scholar 

  10. Milman N, Hoffmann AL, Byg KE (1998) Sarcoidosis in children. Epidemiology in Danes, clinical features, diagnosis, treatment and prognosis. Acta Paediatr 87:871–878

    Article  PubMed  CAS  Google Scholar 

  11. Narla LD, Hingsbergen EA, Jones JE (1999) Adult diseases in children. Pediatr Radiol 29:244–254

    Article  PubMed  CAS  Google Scholar 

  12. Nilubol N, Taub PJ, Venturero M, Lichtiger S, Bauer JJ (2001) Ulcerative colitis and sarcoidosis. Mt Sinai J Med 68:400–403

    PubMed  CAS  Google Scholar 

  13. Puntis JWL, Tarlow MJ, Raafat F, Weller PH, Booth IW (1990) Crohn’s disease of the lung. Arch Dis Child 65:1270–1271

    PubMed  CAS  Google Scholar 

  14. Raven RW (1949) The surgical manifestations of sarcoidosis. Ann R Coll Surg Engl 5:3–28

    PubMed  CAS  Google Scholar 

  15. Shetty AK, Gedalia A (1998) Sarcoidosis: a pediatric perspective. Clin Pediatr (Phila) 37:707–717

    Article  CAS  Google Scholar 

  16. Stampfl DA, Grimm IS, Barbot DJ, Rosato FE, Gordon SJ (1990) Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations. Dig Dis Sci 35:526–532

    Article  PubMed  CAS  Google Scholar 

  17. Tuohy KA, Steinmann TI (2005) Hypercalcemia due to excess 1,25-dihydroxyvitamin D in Crohn’s disease. Am J Kidney Dis 45:3–6

    Article  Google Scholar 

  18. Veitch A, Badger I (2004) Sarcoidosis presenting as colonic polyposis: report of a case. Dis Colon Rectum 47:937–939

    Article  PubMed  Google Scholar 

  19. Weiss A, Mayer L (1997) Extraintestinal manifestations of inflammatory bowel disease. In: Allan RN (ed) Inflammatory bowel diseases. Churchill Livingstone, New York, pp 623–632

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jürgen Brunner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brunner, J., Sergi, C., Müller, T. et al. Juvenile sarcoidosis presenting as Crohn’s Disease. Eur J Pediatr 165, 398–401 (2006). https://doi.org/10.1007/s00431-005-0059-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-005-0059-y

Keywords

Navigation