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Ischaemic cholangiopathy and sickle cell disease

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Abstract

We report a case of a 6-year-old girl of Afro-Caribbean origin, known to have sickle cell disease (SCD), with recurrent history of jaundice and abdominal pain. She was extensively investigated, including endoscopic retrograde cholangiopancreatography (ERCP), which revealed diffuse cholangiopathy of both extrahepatic and intrahepatic bile ducts. A pigtail stent was placed and balloon dilatation was performed for stricture of the extrahepatic duct. Since then, she remains well and asymptomatic. We suggest that cholangiopathy is the consequence of sickling in the end arteries of the biliary arterial tree.

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Authors and Affiliations

  1. Institute of Liver Studies, King’s College Hospital, London, UK

    Mansoor Ahmed, Giorgina Mieli-Vergani, Phil Harrison & Anil Dhawan

  2. Department of Haematology, King’s College Hospital, London, UK

    Moira Dick

  3. Department of Radiology, King’s College Hospital, London, UK

    John Karani

  4. Paediatric Liver Service, King’s College Hospital, Denmark Hill, London, SE5 9RS, UK

    Anil Dhawan

Authors
  1. Mansoor Ahmed
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  2. Moira Dick
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  3. Giorgina Mieli-Vergani
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  4. Phil Harrison
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  5. John Karani
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  6. Anil Dhawan
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Corresponding author

Correspondence to Anil Dhawan.

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Ahmed, M., Dick, M., Mieli-Vergani, G. et al. Ischaemic cholangiopathy and sickle cell disease. Eur J Pediatr 165, 112–113 (2006). https://doi.org/10.1007/s00431-005-0005-z

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  • DOI: https://doi.org/10.1007/s00431-005-0005-z

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