Four preterm newborn infants with severe multisystem Coxsackie virus B infection were treated with an oral suspension of pleconaril (5 mg/kg per day). The patients had myocarditis, fulminant hepatitis, meningoencephalitis and disseminated intravascular coagulopathy. All four infants recovered, and no adverse effects of the treatment were noted. Conclusion: pleconaril needs to be comprehensively evaluated in this population.
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Bauer, S., Gottesman, G., Sirota, L. et al. Severe Coxsackie virus B infection in preterm newborns treated with pleconaril. Eur J Pediatr 161, 491–493 (2002). https://doi.org/10.1007/s00431-002-0929-5
- Coxsackie virus Enterovirus Neonate Pleconaril