Abstract.
We describe a case-control study to identify associations between polymorphism at the glutathione S-transferase loci and susceptibility to childhood malignancy.
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Chen CL, Liu Q, Pui CH, Rivera GK, Sandlund JT, Ribeiro R, Evans WE, Relling MV (1997) Higher frequency of glutathioneS-transferase deletions in black children with acute lymphoblastic leukemia. Blood 89: 1701–1707
Krajinovic M, Labuda D, Richer Ch, Karimi S, Sinnett D (1999) Susceptibility to childhood acute lymphoblastic leukemia: influence of CYPIA1, CYP2D6, GSTMI, and GSTTI genetic polymorphisms. Blood 93: 1496–1501
Lin HJ, Han ChY, Bernstein DA, Hsiao W, Lin BK, Hardy S (1994) Ethnic distribution of the glutathione transferase Mu 1-1 (GSTMI) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis 15: 1077–1081
Mannervik B, Wildersten M (1995) Human glutathione transferases: classification, tissue distribution, structure, and functional properties. In: Pacifici GM, Fracchia GN (eds) Advances in drug metabolism in man. European Commission ECSCEC-EAEC, Brussels, Luxembourg pp 408–459
Nelson HH, Wienckie JK, Christiani DC, Cheng TJ, Zuo ZF, Schwartz BS, Lee BK, Spitz MR, Wang M, Xu X, Kelsey KT (1995) Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione-S-transferase theta. Carcinogenesis 16: 1243–1245
Zhang H, Ahmadi A, Arbman G, Zdolsek J, Carstensen J, Nordenskjöld B, Söderkvist P, Sun X (1999) GlutathioneS-transferase TI and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma Int J Cancer 84: 135–138
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Zielinska, E., Zubowska, M., Przybylowska, K. et al. Frequency of glutathione-S-transferase gene deletions in children with neoplasms. Eur J Pediatr 161, 63–64 (2002). https://doi.org/10.1007/s00431-001-0857-9
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DOI: https://doi.org/10.1007/s00431-001-0857-9