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High prevalence of human papillomaviruses in Ghanaian pregnant women

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Abstract

Data about the prevalence of human papillomaviruses (HPV) in African women with normal and abnormal cervical cytology are still scarce. Current HPV vaccines contain HPV types, which mainly represent the HPV epidemiology of industrial countries. As further developments of HPV vaccines are going on, it is necessary to regard regional differences in HPV type prevalence to ensure optimal protection by the vaccine. Vaginal swabs of Ghanaian pregnant women, routinely collected before delivery to rule out bacterial infections causing early onset sepsis, were screened for 12 high-risk (HR), 13 probably/possibly (pHR), and 18 low-risk (LR) HPV types. Most pregnant women come for delivery to the hospital. This was considered as appropriate possibility to have an unselected group of women. HPV DNA were detected in 55/165 women (33.3, 95 % CI 26.3–41.1 %). Thirty-four out of fifty-five (61.8, 95 % CI 47.7–74.3 %) of HPV-positive women were infected with HR and/or pHR HPV types. The five most prevalent HR or pHR HPV types were HPV-52 and HPV-67 (7 women each, 4.2, 95 % CI 1.9–8.9 %), HPV-53 (six women, 3.6, 95 % CI 1.5–8.1 %), HPV-45 (five women, 3.0, 95 % CI 1.1–7.3 %), and HPV-18 (four women, 2.4, 95 % CI 0.8–6.5 %), respectively. HPV-16 was found in two women only (1.2, 95 % CI 0.2–4.8 %). Future HPV vaccine research may devote special interest to HPV-67 and HPV-53 provided further studies confirm their high prevalence in the general population of Sub-Saharan African countries. The true carcinogenic potential of HPV-67, which is a member of species alpha9 including HPV-16, and so far categorized as pHR, should be clarified.

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Acknowledgments

We would like to thank Nabila Ristow and Monika Junk from the German National Reference Centre for Papilloma- and Polyomaviruses, University of Cologne, for their excellent technical assistance. We are also grateful to Klaus Jung, Ph.D., and his colleagues from the Department of Medical Statistics, University of Göttingen, for their valuable support in statistical analysis of the data. This study was presented in part as a poster at the 30th International Papillomavirus Conference, Lisbon, Portugal, 17–21 September 2015, in part as a talk at the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, United States, 17–21 September 2015, and in part as a poster at the 26th Annual Meeting of the Society of Virology, Münster, Germany, 6–9 April 2016.

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Correspondence to Marco H. Schulze.

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The authors declare that they have no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the ethical committee of the University Medical Center Göttingen, Germany (number 14/10/11), and the authority of the St. Martin de Porres Hospital in Eikwe, Ghana.

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Informed consent was obtained from all individual participants included in the study.

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Marco H. Schulze and Fabian M. Völker have equally contributed to this work.

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Schulze, M.H., Völker, F.M., Lugert, R. et al. High prevalence of human papillomaviruses in Ghanaian pregnant women. Med Microbiol Immunol 205, 595–602 (2016). https://doi.org/10.1007/s00430-016-0475-9

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