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HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort

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Abstract

In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient’s HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whereas with viral load that relationship was direct. Certain HLA types and viral subtypes were also found to associate with patients’ viral load. Associations between disease parameters and the genetic makeup of the host and virus may be crucial in determining the outcome of HIV-1 infection.

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Acknowledgments

For this study, Syed Hani Abidi’s training was funded by HIV Research Trust (Scholarship No. HIVRT 10-059).

Conflict of interest

Authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Biological and Biomedical Sciences, Aga Khan University, P.O. Box 3500, Karachi, 74800, Pakistan

    Syed Hani Abidi, Aniqa Shahid & Syed Ali

  2. Medical College, Aga Khan University, Karachi, Pakistan

    Laila S. Lakhani

  3. Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya

    Reena Shah

  4. Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya

    Nancy Okinda & Peter Ojwang

  5. Department of Surgery, Aga Khan University, Karachi, Pakistan

    Farhat Abbas

  6. MRC Human Immunology Unit, Oxford University, Oxford, UK

    Sarah Rowland-Jones

Authors
  1. Syed Hani Abidi
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  2. Aniqa Shahid
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  3. Laila S. Lakhani
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  4. Reena Shah
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  5. Nancy Okinda
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  6. Peter Ojwang
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  7. Farhat Abbas
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  8. Sarah Rowland-Jones
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  9. Syed Ali
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Corresponding author

Correspondence to Syed Ali.

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Abidi, S.H., Shahid, A., Lakhani, L.S. et al. HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort. Med Microbiol Immunol 203, 57–63 (2014). https://doi.org/10.1007/s00430-013-0314-1

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  • DOI: https://doi.org/10.1007/s00430-013-0314-1

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