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“Trivalent influenza vaccination of healthy adults 3 years after the onset of swine-origin H1N1 pandemic: restricted immunogenicity of the new A/H1N1v constituent?”

Medical Microbiology and Immunology volume 202, pages 125–130 (2013)Cite this article

Abstract

Influenza vaccination is advised annually to reduce the burden of influenza disease. For sufficient vaccine campaigns also a continuous adoption of influenza vaccines are necessary, due to particularly high genetic variability of influenza A virus. Therefore, we evaluate the effectiveness of the trivalent influenza vaccine 2010/2011, against influenza A (H1N1, H3N2) and influenza B. Immune response was investigated in paired sera from 92 healthcare workers with the hemagglutination inhibition assay (HI). Protective antibody levels (HI titer ≥40) were found after vaccination for influenza A/California/07/2009(H1N1): 84.71 % [GMT: 115.34]; for influenza A/Perth/16/2009(H3N2): 94.94 % [GMT: 268.47] and for influenza B/Brisbane/60/2008: 96.20 % [GMT: 176.83]; matching with the currently circulating virus strains. However, the highest seroprevalence rate was found against influenza B; pre- and post-vaccination titers as well, which may be due to comparatively high virus preservation. Remarkable, lowest seropositivity was seen against H1N1. Despite the significant titer rise, sufficient H1N1 herd immunity was still not achieved. It can be assumed that a high influenza A herd immunity may be a requirement for a successful booster vaccination.

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Acknowledgments

Our very special thanks go to the serological medical technical assistants at the Institute of Medical Virology Frankfurt/Main, for their excellent work.

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Affiliations

  1. Institute of Medical Virology and Travel Vaccination Centre, J. W. Goethe University Clinic Frankfurt/Main, Paul-Ehrlich Str. 40, 60596, Frankfurt/Main, Germany

    R. Allwinn & I. Friedrichs

  2. HIVCENTER, J. W. Goethe University Clinic Frankfurt/Main, 60590, Frankfurt/Main, Germany

    M. Bickel & C. Lassmann

  3. Occupational Health Service, J. W. Goethe University Clinic Frankfurt/Main, 60590, Frankfurt/Main, Germany

    S. Wicker

Authors
  1. R. Allwinn
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  2. M. Bickel
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  3. C. Lassmann
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  4. S. Wicker
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  5. I. Friedrichs
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Correspondence to R. Allwinn.

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Allwinn, R., Bickel, M., Lassmann, C. et al. “Trivalent influenza vaccination of healthy adults 3 years after the onset of swine-origin H1N1 pandemic: restricted immunogenicity of the new A/H1N1v constituent?”. Med Microbiol Immunol 202, 125–130 (2013). https://doi.org/10.1007/s00430-012-0259-9

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  • DOI: https://doi.org/10.1007/s00430-012-0259-9

Keywords

  • Trivalent influenza vaccination
  • Restricted immune response to H1N1v
  • High influenza B and A/H3N2 seropositivity rates
  • Hemagglutination inhibition assay