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Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients

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An Erratum to this article was published on 30 October 2010

Abstract

In HIV-infected treatment-naïve patients, we analyzed risk factors for either chronic hepatitis B (HBV) infection, occult HBV infection (OHBV) or a positive hepatitis C (HCV) serostatus. A total of 918 patients of the RESINA-cohort in Germany were included in this study. Before initiating antiretroviral therapy, clinical parameters were collected and blood samples were analyzed for antibodies against HIV, HBV and HCV, HBs antigen and viral nucleic acids for HIV and HBV. Present or past HBV infection (i.e. HBsAg and/or anti-HBc) was found in 43.4% of patients. HBsAg was detected in 4.5% (41/918) and HBV DNA in 6.1% (34/554), resulting in OHBV infection in 2.9% (16/554) of patients. OHBV infection could not be ruled out by the presence of anti-HBs (50.1%) or the absence of all HBV seromarkers (25%). A HCV-positive serostatus was associated with the IVDU transmission route, non-African ethnicity, elevated liver parameters (ASL or GGT) and low HIV viral load. Replicative HBV infection and HCV-positive serostatus both correlated with HIV resistance mutations (P = 0.001 and P = 0.028). HBV and HCV infection are frequent co-infections in HIV treatment-naive patients. These co-infections influence viral evolution, clinical parameters and serological markers. Consequently, HIV patients should routinely be tested for HBV and HCV infection before initiating HIV treatment. OHBV infection constituted almost half of all HBV infections with detectable HBV DNA. Due to a lack of risk factors indicating OHBV infection, HBV diagnosis should not only include serological markers but also the detection of HBV DNA.

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Acknowledgments

The RESINA study is supported by a grant from the German Ministry of Health and Social Security (grant no. AZ 319-4476-02/3). We are indebted to Professor W. H. Gerlich for fruitful discussion and critical reading of the manuscript. We would like to thank Eugen Schülter, Claudia Müller and Angelika Hergesell for valuable help in data acquisition.

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Authors and Affiliations

  1. Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany

    Stefan Reuter & Dieter Häussinger

  2. Clinic of General Medicine, Gastroenterology and Infectious Diseases, Augustinerinnen Hospital, Cologne, Germany

    Mark Oette

  3. Institute of Virology, University of Cologne, Cologne, Germany

    Frank Clemens Wilhelm, Rolf Kaiser, Melanie Balduin, Finja Schweitzer, Jens Verheyen & Herbert Pfister

  4. Max Planck Institute for Informatics, Computational Biology and Applied Algorithmics, Saarbruecken, Germany

    Bastian Beggel & Thomas Lengauer

  5. Institute of Virology, University Hospital of Düsseldorf, Düsseldorf, Germany

    Ortwin Adams

  6. Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany

    Gerd Fätkenheuer

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  1. Stefan Reuter
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  2. Mark Oette
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Correspondence to Stefan Reuter.

Additional information

S. Reuter and M. Oette contributed equally to this work.

This study is conducted for the RESINA study group.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00430-010-0179-5

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Reuter, S., Oette, M., Wilhelm, F.C. et al. Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients. Med Microbiol Immunol 200, 39–49 (2011). https://doi.org/10.1007/s00430-010-0172-z

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