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Seroprevalence of human T-cell lymphotropic virus type 1 and 2 in blood donors from the regional hospital of Valdivia, Chile

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Abstract

It is estimated that 15–20 millions of people are infected with human T-cell lymphotropic virus 1/2 (HTLV-1/2) worldwide, and 20–30% of them are Latin Americans. The seroprevalence rates vary according to geographic area, socio-demographic composition and individual risk behaviors. The impact of HTLV-1-associated diseases on the community, as well as the increasing concerns about blood transfusion safety due to infectious transmitted agents, has required mandatory screening assays of blood donors as an effective preventive strategy in HTLV-1 transmission. The aim of this study was to estimate the seroprevalence of HTLV-1/2 in blood donors from Valdivia, southern Chile during the first year of mandatory screening of HTLV by Chilean government. Blood samples were collected from blood donors between May 2009 and 2010 at the Regional Hospital of Valdivia, Chile. Serum samples were screened for antibodies against HTLV-1/2 by enzyme-linked immunosorbent assay MUREX HTLV I + II Abbott. Among 6,237 samples tested by serological assay, 28 samples were reactive; nevertheless, confirmatory techniques indicate that only 15 samples were positive to HTLV-1. Our study shows HTLV-1 seroprevalence of 0.24%, indicating a similar seroprevalence associated with blood donors than previous reports for our country.

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References

  1. Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL (2005) Global epidemiology of HTLV-I infection and associated diseases. Oncogene 24:6058–6068

    Article  CAS  PubMed  Google Scholar 

  2. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415–7419

    Article  CAS  PubMed  Google Scholar 

  3. Yoshida M, Miyoshi I, Hinuma Y (1982) Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79:2031–2035

    Article  CAS  PubMed  Google Scholar 

  4. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A et al (1986) HTLV-I associated myelopathy, a new clinical entity. Lancet 1:1031–1032

    Article  CAS  PubMed  Google Scholar 

  5. Barmak K, Harhaj E, Grant C, Alefantis T, Wigdahl B (2003) Human T cell leukemia virus ype I-induced disease: pathways to cancer and neurodegeneration. Virology 308:1–12

    Article  CAS  PubMed  Google Scholar 

  6. Edlich RF, Arnette JA, Williams FM (2000) Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I). J Emerg Med 18:109–119

    Article  CAS  PubMed  Google Scholar 

  7. Galvao-Castro B, Loures L, Rodriques LG, Sereno A, Ferreira OC Jr, Franco LG et al (1997) Distribution of human T-lymphotropic virus type I among blood donors: a nationwide Brazilian study. Transfusion 37:242–243

    Article  CAS  PubMed  Google Scholar 

  8. Kazanji M, Gessain A (2003) Human T-cell lymphotropic virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology. Cad Saude Pub 19:1227–1240

    Google Scholar 

  9. Leon G, Quiros AM, Lopez JL, Hung M, Diaz AM, Goncalves J et al (2003) Seropositivity for human T-lymphotropic virus types I and II among donors at the municipal blood bank of caracas and associated risk factors. Rev Panam Salud Pub 13:117–123

    Google Scholar 

  10. Sanchez-Palacios C, Gotuzzo E, Vandamme AM, Maldonado Y (2003) Seroprevalence and risk factors for human T-cell lymphotropic virus (HTLV-I) infection among ethnically and geographically diverse peruvian women. Int J Infect Dis 7:132–137

    Article  CAS  PubMed  Google Scholar 

  11. Gastaldello R, Hall WW, Gallego S (2004) Seroepidemiology of HTLV-I/II in Argentina: an overview. J Acq Immun Def Synd 35:301–308

    Article  Google Scholar 

  12. Zaninovic V, Sanson F, Lopez F, Velandia G, Blank A, Blank M et al (1993) Geographic independence of HTLV-I and HTLV-II foci in the andes highland, the Atlantic coast, and the orinoco of Colombia. AIDS Res Hum Retrovir 10:97–101

    Article  Google Scholar 

  13. Cartier L, Tajima K, Araya F, Castillo JL, Zaninovic V, Hayami M et al (1993) Preliminary report on the prevalence of serum antibodies against HTLV-I in Chilean aboriginal populations. Rev Med Chile 121:242–246

    Google Scholar 

  14. Inostroza J, Diaz P, Saunier C (1991) Prevalence of antibodies to HTLV-1 in south American Indians (Mapuches) from Chile. Scand J Infect Dis 23:507–508

    Article  CAS  PubMed  Google Scholar 

  15. Vasquez P, Sánchez G, Volante C, Vera L, Ramírez E, Soto G et al (1991) Human T-Lymphotropic virus type I: new risk for Chilean population. Blood 78:850–851

    CAS  PubMed  Google Scholar 

  16. Vasquez P (2003) HTLV-I (Human T–cell lymphotropic virus), algo que decir? Rev Chil Infect 20(Supl 1):S34–S37

    Google Scholar 

  17. Cartier L, Cartier E (1996) HTLV-I-II in Chile. In: Zaninovic V (ed) HTLV, truths and questions. Fund. Mar, Cali, pp 150–158

    Google Scholar 

  18. Cartier L, Mora C, Araya J, Castillo J, Verdugo R, Miller MA et al (1989) HTLV-I positive spastic paraparesis in a temperate zone. Lancet 1:556–557

    Google Scholar 

  19. Galeno H, Ramirez E, Mora J, Ojeda M, Cartier L (1994) Anti HTLV-I antibody titers in seropositive infected individuals. Rev Med Chile 122:1004–1007

    CAS  PubMed  Google Scholar 

  20. Cartier L, Araya F, Castillo JL, Verdugo R, Mora C, Gajdusek DC, Gibbs C (1990) HTLV-I provirus in Chile, study of 140 neurological patients. Rev Med Chile 118:622–628

    CAS  PubMed  Google Scholar 

  21. Galeno H, Ramirez E, Cartier L (1996) HTLV-I provirus in seronegative chilean patients with tropical spastic paraparesis. Lancet 348:1170

    Article  CAS  PubMed  Google Scholar 

  22. Ramirez E, Cartier L, Flores R (2004) In vitro cytoskeleton changes of mouse neurons induced by purified HTLV-I, and PBMC from HAM/TSP patients and HTLV-I carriers. Arch Virol 149:2307–2317

    Article  CAS  PubMed  Google Scholar 

  23. Ramirez E, Cartier L, Torres M, Barria M (2007) Temporal dynamics of human T-lymphotropic virus type I tax mRNA and proviral DNA load in peripheral blood mononuclear cells of human T-lymphotropic virus type I-associated myelopathy patients. J Med Virol 79:782–790

    Article  CAS  PubMed  Google Scholar 

  24. Li HC, Fujiyoshi T, Lou H, Yashiki S, Sonoda S, Cartier L et al (1999) The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an andean mummy. Nat Med 5:1428–1432

    Article  CAS  PubMed  Google Scholar 

  25. Cartier L, Araya F, Castillo JL, Zaninovic V, Hayami M, Miura T et al (1993) Southern-most carriers of HTLV-I/II in the world. Jpn J Cancer Res 84:1–3

    CAS  PubMed  Google Scholar 

  26. Uchiyama T (1997) Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol 15:15–37

    Article  CAS  PubMed  Google Scholar 

  27. Manns A, Wilks RJ, Murphy EL, Haynes G, Figueroa JP, Barnett M et al (1992) A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion. Int J Cancer 51:886–891

    Article  CAS  PubMed  Google Scholar 

  28. Berini CA, Susana Pascuccio M, Bautista CT, Gendler SA, Eirin ME, Rodriguez C, Pando MA, Biglione MM (2008) Comparison of four commercial screening assays for the diagnosis of human T-cell lymphotropic virus types 1 and 2. J Virol Methods 147:322–327

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors would like to thank Omar A. Oyarzabal, Department of Biological Sciences, Alabama State University, for his help in preparing the manuscript. The study was supported by Grant S-2008-21 from Dirección de Investigación y Desarrollo-Universidad Austral de Chile and Coldas-Virología from Servicio Salud Valdivia-Universidad Austral de Chile.

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Correspondence to Carola Otth.

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Chandía, L., Sotomayor, C., Ordenes, S. et al. Seroprevalence of human T-cell lymphotropic virus type 1 and 2 in blood donors from the regional hospital of Valdivia, Chile. Med Microbiol Immunol 199, 341–344 (2010). https://doi.org/10.1007/s00430-010-0166-x

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  • DOI: https://doi.org/10.1007/s00430-010-0166-x

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