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Does the proper intravenous immunoglobulin substitution in primary immunodeficiency protect against HBV infections?: a description of a case series

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Abstract

There are no recommendations concerning preoperative management of primary immunodeficiency patients in cases of emergency or planned surgery in relation to risk of hepatitis type B virus infection. To assess if immunodeficient patients regularly supplemented with immunoglobulins are protected against hepatitis B. IgG, IgM and IgA total levels and anti-HBs level were estimated in adult patients with primary humoral immunodeficiency before and after immunoglobulins supplementation according to a standardized schedule. Serum IgG and anti-HBs level significantly increased after immunoglobulin supplementation. Anti-HBs titer increased in all cases over 100 IU/L regardless of initial total IgG serum value, reaching a highly protective level. There was no correlation between increase in concentration of IgG (ΔIgG) versus Δanti-HBs in the studied patients. Patients with primary hypogammaglobulinemia supplemented with immunoglobulin are protected against hepatitis type B.

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Abbreviations

IVIG:

Intravenous immunoglobulin

PID:

Primary immunodeficiency

HBs:

Surface antigen of hepatitis type B

CVID:

Common variable immunodeficiency

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Authors and Affiliations

  1. Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. 3 Maja 13-15, 41-800, Zabrze, Poland

    Glück Joanna, Żeglen Slawomir, Rymarczyk Barbara & Rogala Barbara

Authors
  1. Glück Joanna
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  2. Żeglen Slawomir
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  3. Rymarczyk Barbara
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  4. Rogala Barbara
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Correspondence to Glück Joanna.

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Joanna, G., Slawomir, Ż., Barbara, R. et al. Does the proper intravenous immunoglobulin substitution in primary immunodeficiency protect against HBV infections?: a description of a case series. Med Microbiol Immunol 197, 325–328 (2008). https://doi.org/10.1007/s00430-008-0075-4

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  • DOI: https://doi.org/10.1007/s00430-008-0075-4

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