Medical Microbiology and Immunology

, Volume 196, Issue 3, pp 165–170 | Cite as

Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity

  • Ben Yu-Jih Su
  • Cheng-Yu Su
  • Shan-Fu Yu
  • Chung-Jen ChenEmail author
Original Investigation


We try to find the association of cytomegalovirus (CMV) infection and anti-β2 glycoprotein 1 autoantibodies (anti-β2 GP1), a key antibody in antiphospholipid syndrome (APS), among systemic lupus erythematosus (SLE) and cerebral vascular accident (CVA) patients. This retrospective study enrolled serum samples obtained from 87 SLE and 97 CVA patients who have been checked for the existence of anti-β2 GP1. First, the prevalence rate of anti-CMV IgG and IgM in patients with and without anti-β2 GP1 were compared. Second, the prevalence of anti-CMV IgG and IgM were compared between SLE and CVA patients. Last, this study analyzed the clinical characteristics and disease activity in SLE patients with positive anti-CMV IgM and IgG. No difference existed in the prevalence rate of anti-CMV IgG and IgM between positive or negative anti-β2 GP1 serum samples in both SLE and CVA patients. However, the prevalence of anti-CMV IgM was significantly higher in the SLE group than in the CVA group. Severity of clinical features and SLEDAI scores were considerably higher in patients with positive anti-CMV IgM than in SLE patients with negative anti-CMV IgM. Very impressively, all IgM-positive SLE samples (9/9) carrying highest levels of anti-CMV IgG, indicated reactivation of the latent CMV infection. Hence, it suggests that CMV reactivation might contribute toward the disease flare in some SLE patients. In future, a prospective and longitudinal study is stongly indicated.


Systemic lupus erythematosus Cytomegalovirus Anti-β2 glycoprotein 1 autoantibodies Cerebral vascular accident 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ben Yu-Jih Su
    • 1
  • Cheng-Yu Su
    • 2
  • Shan-Fu Yu
    • 1
  • Chung-Jen Chen
    • 1
    Email author
  1. 1.Division of Allergy, Immuology and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiung HseinTaiwan
  2. 2.Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiung HseinTaiwan

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