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Expression of CD83 in the murine immune system

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Abstract

CD83 is used as a marker for mature dendritic cells (DC) in man. We have developed a new monoclonal antibody (mAb), Michel-17, that specifically recognizes mouse CD83. We show that murine CD83 is expressed mainly on mature DC and on activated T cells. Histological analysis of serial spleen sections revealed a CD83 expression pattern resembling that of MIDC-8, a known murine DC marker molecule. In contrast to other costimulatory receptors, cross-linking of CD83 with the mAb Michel-17 on DC or T cells does not induce any activation signals. Our data describe for the first time the expression pattern of murine CD83, which is comparable to that of human CD83.The unique mAb Michel-17 will help to elucidate the biological functions of the CD83 molecule in more detail.

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Acknowledgments

We thank Michael Schreiber for assistance in preparing the computer images and Ken Pfarr for critical reading of the manuscript.

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Authors and Affiliations

  1. Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359, Hamburg, Germany

    Matthias Wolenski, Sven O. Cramer, Svenja Ehrlich, Christiane Steeg, Gudrun Großschupff, Klara Tenner-Racz, Paul Racz, Bernhard Fleischer & Arne von Bonin

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  1. Matthias Wolenski
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  2. Sven O. Cramer
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  3. Svenja Ehrlich
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  4. Christiane Steeg
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  5. Gudrun Großschupff
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  6. Klara Tenner-Racz
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  7. Paul Racz
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  8. Bernhard Fleischer
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  9. Arne von Bonin
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Corresponding author

Correspondence to Arne von Bonin.

Additional information

M. Wolenski's Ph.D. thesis contains parts of these data.

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Wolenski, M., Cramer, S.O., Ehrlich, S. et al. Expression of CD83 in the murine immune system. Med Microbiol Immunol 192, 189–192 (2003). https://doi.org/10.1007/s00430-003-0179-9

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  • DOI: https://doi.org/10.1007/s00430-003-0179-9

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