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Medical Microbiology and Immunology

, Volume 192, Issue 2, pp 93–97 | Cite as

Immunity against diphtheria and tetanus in German blood donors

  • Arne Aue
  • Holger Hennig
  • Sabine Krüger
  • Barbara Closius
  • Holger Kirchner
  • Michael Seyfarth
Original Investigation
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Abstract.

After the recent diphtheria epidemics in Eastern Europe in the early 1990s, we re-evaluated the diphtheria and tetanus immunity of 321 German blood donors (192 men and 129 women). The mean antitoxin levels of all blood donors in this study, measured by commercial ELISA, revealed a questionable protection (0.1–1.0 IU/ml) against diphtheria. In 1994, 66.4% were without immunity against diphtheria (55.0% in 1997/98), 32.1% (41.5% in 1997/98) showed questionable protection and only 1.5% (3.5% in 1997/98) had protective antitoxin levels. The evaluation of tetanus immunity revealed only 0.5% (1.1% in 1997/98) of the subjects with no protection and 9.1% (8.5% in 1997/98) with questionable protection. For this reason, we conclude that the diphtheria epidemics only lead to an insufficient improvement of the immunization status in a healthy German population.

Diphtheria Tetanus Immunity Vaccination 

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Arne Aue
    • 1
  • Holger Hennig
    • 2
  • Sabine Krüger
    • 2
  • Barbara Closius
    • 2
  • Holger Kirchner
    • 2
  • Michael Seyfarth
    • 1
  1. 1.Institute of Clinical Chemistry, University of Lübeck, Lübeck, Germany
  2. 2.Institute of Immunology and Transfusion Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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