Abstract
Astrocyte elevated gene-1 (AEG-1) is a well-known oncogene implicated in various types of human cancers, including brain tumors. Recently, AEG-1 has also been reported to play pivotal roles in glioma-associated neurodegeneration and neurodegenerative diseases like Parkinson's disease and amyotrophic lateral sclerosis. However, the normal physiological functions and expression patterns of AEG-1 in the brain are not well understood. In this study, we investigated the expression patterns of AEG-1 in the normal mouse brain and found that AEG-1 is widely expressed in neurons and neuronal precursor cells, but little in glial cells. We observed differential expression levels of AEG-1 in various brain regions, and its expression was mainly localized in the cell body of neurons rather than the nucleus. Additionally, AEG-1 was expressed in the cytoplasm of Purkinje cells in both the mouse and human cerebellum, suggesting its potential role in this brain region. These findings suggest that AEG-1 may have important functions in normal brain physiology and warrant further investigation. Our results may also shed light on the differential expression patterns of AEG-1 in normal and pathological brains, providing insights into its roles in various neurological disorders.
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Data Availability Statement
The data that support the findings of this study are available on request from the corresponding authors.
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This study was supported by grants from the National Research Foundation of Korea (NRF-2017R1D1A1B03032218, NRF-2020R1F1A1071525, NRF-2020R1F1A1075178, and NRF-2021R1I1A2054560).
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HK and MC, with guidance from EMH and SGL, designed the experiments, performed the experiments, and analyzed the data. SH, SYP, MSJ, and SRK provided histological assistance and data interpretation. HK, MC, SRK, EMH, and SGL wrote the manuscript. All authors contributed to the scientific insights and provided critical inputs to the manuscript. All authors contributed to the manuscript preparation, read it, and approved the submitted version.
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Kim, H., Choi, M., Han, S. et al. Expression patterns of AEG-1 in the normal brain. Brain Struct Funct 228, 1629–1641 (2023). https://doi.org/10.1007/s00429-023-02676-1
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DOI: https://doi.org/10.1007/s00429-023-02676-1