Abstract
Spatially remote brain regions show synchronized activity as typically revealed by correlated functional MRI (fMRI) signals. An emerging line of research has focused on the temporal fluctuations of connectivity; however, its relationships with stationary connectivity have not been clearly illustrated. We examined dynamic and stationary connectivity when the participants watched four different movie clips. We calculated point-by-point multiplication between two regional time series to estimate the time-resolved dynamic connectivity, and estimated the inter-individual consistency of the dynamic connectivity time series. Widespread consistent dynamic connectivity was observed for each movie clip, which also showed differences between the clips. For example, a cartoon movie clip, Wall-E, showed more consistent of dynamic connectivity with the posterior cingulate cortex and supramarginal gyrus, while a court drama clip, A Few Good Men, showed more consistent of dynamic connectivity with the auditory cortex and temporoparietal junction, which might suggest the involvement of specific brain processing for different movie contents. In contrast, the stationary connectivity as measured by the correlations between regional time series was highly similar among the movie clips, and showed fewer statistically significant differences. The patterns of consistent dynamic connectivity could be used to classify different movie clips with higher accuracy than the stationary connectivity and regional activity. These results support the functional significance of dynamic connectivity in reflecting functional brain changes, which could provide more functionally relevant information than stationary connectivity.
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Data availability
This study is a secondary analysis of publicly available data sets. The download links for the data sets are provided in the manuscript. No personal identifiable information was used in the current study.
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This study was supported by (US) National Institutes of Health Grants R15MH125332 (XD), R01MH131335 (BB), and R01AT009829 (BB).
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XD contributed to the study conception and data analysis. All authors have discussed the results. The first draft of the manuscript was written by XD and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Di, X., Zhang, Z., Xu, T. et al. Dynamic and stationary brain connectivity during movie watching as revealed by functional MRI. Brain Struct Funct 227, 2299–2312 (2022). https://doi.org/10.1007/s00429-022-02522-w
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DOI: https://doi.org/10.1007/s00429-022-02522-w