Abstract
Despite a growing number of functional MRI studies reporting exercise-induced changes during cognitive processing, a systematic determination of the underlying neurobiological pathways is currently lacking. To this end, our neuroimaging meta-analysis included 20 studies and investigated the influence of physical exercise on cognition-related functional brain activation. The overall meta-analysis encompassing all experiments revealed physical exercise-induced changes in the left parietal lobe during cognitive processing. Subgroup analysis further revealed that in the younger-age group (< 35 years old) physical exercise induced more widespread changes in the right hemisphere, whereas in the older-age group (≥ 35 years old) exercise-induced changes were restricted to the left parietal lobe. Subgroup analysis for intervention duration showed that shorter exercise interventions induced changes in regions connected with frontoparietal and default mode networks, whereas regions exhibiting effects of longer interventions connected with frontoparietal and dorsal attention networks. Our findings suggest that physical exercise interventions lead to changes in functional activation patterns primarily located in precuneus and associated with frontoparietal, dorsal attention and default mode networks.
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References
Allen C (2017) On (not) defining cognition. Synthese 194(11):4233–4249. https://doi.org/10.1007/s11229-017-1454-4
Alty J, Farrow M, Lawler K (2020) Exercise and dementia prevention. Pract Neurol 20(3):234–240. https://doi.org/10.1136/practneurol-2019-002335
Baeck JS, Kim YT, Seo JH et al (2012) Brain activation patterns of motor imagery reflect plastic changes associated with intensive shooting training. Behav Brain Res 234(1):26–32. https://doi.org/10.1016/j.bbr.2012.06.001
Bailey T, Shahabi L, Tarvainen M et al (2019) Moderating effects of the valence of social interaction on the dysfunctional consequences of perseverative cognition: an ecological study in major depression and social anxiety disorder. Anxiety Stress Coping 32(2):179–195. https://doi.org/10.1080/10615806.2019.1570821
Bayne T, Brainard D, Byrne RW et al (2019) What is cognition? Curr Biol 29(13):R608-r615. https://doi.org/10.1016/j.cub.2019.05.044
Bherer L, Erickson KI, Liu-Ambrose T (2013) A review of the effects of physical activity and exercise on cognitive and brain functions in older adults. J Aging Res 2013:657508. https://doi.org/10.1155/2013/657508
Boa Sorte Silva NC, Nagamatsu LS, Gill DP et al (2020) Memory function and brain functional connectivity adaptations following multiple-modality exercise and mind-motor training in older adults at risk of dementia: an exploratory sub-study. Front Aging Neurosci 12:22. https://doi.org/10.3389/fnagi.2020.00022
Boraxbekk CJ, Lundquist A, Nordin A et al (2015) Free recall episodic memory performance predicts dementia ten years prior to clinical diagnosis: findings from the betula longitudinal study. Dement Geriatr Cogn Dis Extra 5(2):191–202. https://doi.org/10.1159/000381535
Bostrom N, Sandberg A (2009) Cognitive enhancement: methods, ethics, regulatory challenges. Sci Eng Ethics 15(3):311–341. https://doi.org/10.1007/s11948-009-9142-5
Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10(3):186–198. https://doi.org/10.1038/nrn2575
Button KS, Ioannidis JP, Mokrysz C et al (2013) Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci 14(5):365–376. https://doi.org/10.1038/nrn3475
Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129(Pt 3):564–583. https://doi.org/10.1093/brain/awl004
Chaddock-Heyman L, Erickson KI, Holtrop JL et al (2014) Aerobic fitness is associated with greater white matter integrity in children. Front Hum Neurosci 8:584. https://doi.org/10.3389/fnhum.2014.00584
Chang YK, Labban JD, Gapin JI et al (2012) The effects of acute exercise on cognitive performance: a meta-analysis. Brain Res 1453:87–101. https://doi.org/10.1016/j.brainres.2012.02.068
Chen AG, Zhu LN, Yan J et al (2016) Neural basis of working memory enhancement after acute aerobic exercise: Fmri study of preadolescent children. Front Psychol 7:1804. https://doi.org/10.3389/fpsyg.2016.01804
Chen FT, Etnier JL, Chan KH et al (2020a) Effects of exercise training interventions on executive function in older adults: a systematic review and meta-analysis. Sports Med 50(8):1451–1467. https://doi.org/10.1007/s40279-020-01292-x
Chen FT, Etnier JL, Chan KH et al (2020b) Effects of exercise training interventions on executive function in older adults: a systematic review and meta-analysis. Sports Med. https://doi.org/10.1007/s40279-020-01292-x
Chen FT, Hopman RJ, Huang CJ et al (2020c) The effect of exercise training on brain structure and function in older adults: a systematic review based on evidence from randomized control trials. J Clin Med. https://doi.org/10.3390/jcm9040914
Coelho FG, Gobbi S, Andreatto CA et al (2013) Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (bdnf): a systematic review of experimental studies in the elderly. Arch Gerontol Geriatr 56(1):10–15. https://doi.org/10.1016/j.archger.2012.06.003
Cohen JA, Verghese J, Zwerling JL (2016) Cognition and gait in older people. Maturitas 93:73–77. https://doi.org/10.1016/j.maturitas.2016.05.005
Cole MW, Ito T, Braver TS (2015) Lateral prefrontal cortex contributes to fluid intelligence through multinetwork connectivity. Brain Connect 5(8):497–504. https://doi.org/10.1089/brain.2015.0357
Crawford LK, Li H, Zou L et al (2020) Hypothesized mechanisms through which exercise may attenuate memory interference. Medicina (Kaunas). https://doi.org/10.3390/medicina56030129
Dauwan M, Begemann MJ, Heringa SM et al (2016) Exercise improves clinical symptoms, quality of life, global functioning, and depression in schizophrenia: a systematic review and meta-analysis. Schizophr Bull 42(3):588–599. https://doi.org/10.1093/schbul/sbv164
de Assis GG, de Almondes KM (2017) Exercise-dependent bdnf as a modulatory factor for the executive processing of individuals in course of cognitive decline. Syst Rev Front Psychol 8:584. https://doi.org/10.3389/fpsyg.2017.00584
de Morton NA (2009) The pedro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother 55(2):129–133. https://doi.org/10.1016/s0004-9514(09)70043-1
Dinoff A, Herrmann N, Swardfager W et al (2017) The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults: a meta-analysis. Eur J Neurosci 46(1):1635–1646. https://doi.org/10.1111/ejn.13603
Duchesne C, Gheysen F, Bore A et al (2016) Influence of aerobic exercise training on the neural correlates of motor learning in Parkinson’s disease individuals. Neuroimage Clin 12:559–569. https://doi.org/10.1016/j.nicl.2016.09.011
Eggermont L, Swaab D, Luiten P et al (2006) Exercise, cognition and Alzheimer’s disease: more is not necessarily better. Neurosci Biobehav Rev 30(4):562–575. https://doi.org/10.1016/j.neubiorev.2005.10.004
Eickhoff SB, Laird AR, Grefkes C et al (2009) Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp 30(9):2907–2926. https://doi.org/10.1002/hbm.20718
Eickhoff SB, Nichols TE, Laird AR et al (2016) Behavior, sensitivity, and power of activation likelihood estimation characterized by massive empirical simulation. Neuroimage 137:70–85. https://doi.org/10.1016/j.neuroimage.2016.04.072
Falck RS, Davis JC, Best JR et al (2019) Impact of exercise training on physical and cognitive function among older adults: a systematic review and meta-analysis. Neurobiol Aging 79:119–130. https://doi.org/10.1016/j.neurobiolaging.2019.03.007
Fan L, Li H, Zhuo J et al (2016) The human brainnetome atlas: a new brain atlas based on connectional architecture. Cereb Cortex 26(8):3508–3526. https://doi.org/10.1093/cercor/bhw157
Fernandes J, Arida RM, Gomez-Pinilla F (2017) Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neurosci Biobehav Rev 80:443–456. https://doi.org/10.1016/j.neubiorev.2017.06.012
Fox MD, Corbetta M, Snyder AZ et al (2006) Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci U S A 103(26):10046–10051. https://doi.org/10.1073/pnas.0604187103
Goldin P, Ziv M, Jazaieri H et al (2012a) Randomized controlled trial of mindfulness-based stress reduction versus aerobic exercise: effects on the self-referential brain network in social anxiety disorder. Front Hum Neurosci 6:295. https://doi.org/10.3389/fnhum.2012.00295
Goldin P, Ziv M, Jazaieri H et al (2012b) Mbsr vs aerobic exercise in social anxiety: Fmri of emotion regulation of negative self-beliefs. Soc Cogn Affect Neurosci 8(1):65–72. https://doi.org/10.1093/scan/nss054
Gourgouvelis J, Yielder P, Murphy B (2017) Exercise promotes neuroplasticity in both healthy and depressed brains: an fmri pilot study. Neural Plast 2017:8305287. https://doi.org/10.1155/2017/8305287
Gronwald T, de Alves BAC, Murillo-Rodriguez E et al (2019) Standardization of exercise intensity and consideration of a dose- response is essential. Commentary on “exercise-linked fndc5/irisin rescues synaptic plasticity and memory defects in alzheimer’s models”, by lourenco et al published 2019 in nature medicine. J Sport Health Sci. 8(4):353–354. https://doi.org/10.1016/j.jshs.2019.03.006
Harada CN, Natelson Love MC, Triebel KL (2013) Normal cognitive aging. Clin Geriatr Med 29(4):737–752. https://doi.org/10.1016/j.cger.2013.07.002
Hardman RJ, Meyer D, Kennedy G et al (2020) Findings of a pilot study investigating the effects of mediterranean diet and aerobic exercise on cognition in cognitively healthy older people living independently within aged-care facilities: the lifestyle intervention in independent living aged care (liilac) study. Curr Dev Nutr. 4(5):077. https://doi.org/10.1093/cdn/nzaa077
Harris JD, Quatman CE, Manring MM et al (2014) How to write a systematic review. Am J Sports Med 42(11):2761–2768. https://doi.org/10.1177/0363546513497567
Hartshorne JK, Germine LT (2015) When does cognitive functioning peak? The asynchronous rise and fall of different cognitive abilities across the life span. Psychol Sci 26(4):433–443. https://doi.org/10.1177/0956797614567339
Hedden T, Gabrieli JD (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 5(2):87–96. https://doi.org/10.1038/nrn1323
Herold F, Aye N, Lehmann N et al (2020a) The contribution of functional magnetic resonance imaging to the understanding of the effects of acute physical exercise on cognition. Brain Sci. https://doi.org/10.3390/brainsci10030175
Herold F, Gronwald T, Scholkmann F et al (2020b) New directions in exercise prescription: is there a role for brain- derived parameters obtained by functional near-infrared spectroscopy? Brain Sci. https://doi.org/10.3390/brainsci10060342
Herold F, Hamacher D, Schega L et al (2018) Thinking while moving or moving while thinking—concepts of motor-cognitive training for cognitive performance enhancement. Front Aging Neurosci 10:228. https://doi.org/10.3389/fnagi.2018.00228
Herold F, Muller P, Gronwald T et al (2019a) Dose-response matters!—a perspective on the exercise prescription in exercise-cognition research. Front Psychol 10:2338. https://doi.org/10.3389/fpsyg.2019.02338
Herold F, Torpel A, Hamacher D et al (2020c) A discussion on different approaches for prescribing physical interventions—four roads lead to rome, but which one should we choose? J Pers Med. https://doi.org/10.3390/jpm10030055
Herold F, Torpel A, Schega L et al (2019b) Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements—a systematic review. Eur Rev Aging Phys Act 16:10. https://doi.org/10.1186/s11556-019-0217-2
Heyn P, Abreu BC, Ottenbacher KJ (2004) The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 85(10):1694–1704. https://doi.org/10.1016/j.apmr.2004.03.019
Hillman CH, Erickson KI, Kramer AF (2008) Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 9(1):58–65. https://doi.org/10.1038/nrn2298
Hotting K, Schickert N, Kaiser J et al (2016) The effects of acute physical exercise on memory, peripheral bdnf, and cortisol in young adults. Neural Plast 2016:6860573. https://doi.org/10.1155/2016/6860573
Hsu CL, Best JR, Davis JC et al (2018) Aerobic exercise promotes executive functions and impacts functional neural activity among older adults with vascular cognitive impairment. Br J Sports Med 52(3):184–191. https://doi.org/10.1136/bjsports-2016-096846
Jacobs HI, Van Boxtel MP, Jolles J et al (2012) Parietal cortex matters in alzheimer’s disease: an overview of structural, functional and metabolic findings. Neurosci Biobehav Rev 36(1):297–309. https://doi.org/10.1016/j.neubiorev.2011.06.009
Jamnick NA, Pettitt RW, Granata C et al (2020) An examination and critique of current methods to determine exercise intensity. Sports Med 50(10):1729–1756. https://doi.org/10.1007/s40279-020-01322-8
Kelley GA, Kelley KS (2017) Exercise and sleep: a systematic review of previous meta-analyses. J Evid Based Med 10(1):26–36. https://doi.org/10.1111/jebm.12236
Kivipelto M, Mangialasche F, Ngandu T (2018) Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol 14(11):653–666. https://doi.org/10.1038/s41582-018-0070-3
Knaepen K, Goekint M, Heyman EM et al (2010) Neuroplasticity—exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med 40(9):765–801. https://doi.org/10.2165/11534530-000000000-00000
Kovacevic A, Mavros Y, Heisz JJ et al (2018) The effect of resistance exercise on sleep: a systematic review of randomized controlled trials. Sleep Med Rev 39:52–68. https://doi.org/10.1016/j.smrv.2017.07.002
Krafft CE, Schwarz NF, Chi L et al (2014) An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity (Silver Spring) 22(1):232–242. https://doi.org/10.1002/oby.20518
Kramer AF, Colcombe S (2018) Fitness effects on the cognitive function of older adults: a meta- analytic study-revisited. Perspect Psychol Sci 13(2):213–217. https://doi.org/10.1177/1745691617707316
Kramer AF, Colcombe SJ, McAuley E et al (2005) Fitness, aging and neurocognitive function. Neurobiol Aging 26(Suppl 1):124–127. https://doi.org/10.1016/j.neurobiolaging.2005.09.009
Laird AR, Robinson JL, McMillan KM et al (2010) Comparison of the disparity between talairach and mni coordinates in functional neuroimaging data: validation of the Lancaster transform. Neuroimage 51(2):677–683. https://doi.org/10.1016/j.neuroimage.2010.02.048
Li L, Zhang S, Cui J et al (2019) Fitness-dependent effect of acute aerobic exercise on executive function. Front Physiol 10:902. https://doi.org/10.3389/fphys.2019.00902
Liu-Ambrose T, Barha CK, Best JR (2018) Physical activity for brain health in older adults. Appl Physiol Nutr Metab 43(11):1105–1112. https://doi.org/10.1139/apnm-2018-0260
Liu-Ambrose T, Nagamatsu LS, Voss MW et al (2012) Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol Aging 33(8):1690–1698. https://doi.org/10.1016/j.neurobiolaging.2011.05.010
Liu H, Qin W, Li W et al (2013) Connectivity-based parcellation of the human frontal pole with diffusion tensor imaging. J Neurosci 33(16):6782–6790. https://doi.org/10.1523/jneurosci.4882-12.2013
Lj G (2006) Brodmann’s localisation in the cerebral cortex. Springer, New York
Logothetis NK, Pauls J, Augath M et al (2001) Neurophysiological investigation of the basis of the fmri signal. Nature 412(6843):150–157. https://doi.org/10.1038/35084005
Loprinzi PD, Blough J, Crawford L et al (2019) The temporal effects of acute exercise on episodic memory function: systematic review with meta-analysis. Brain Sci. 9(4):87
Ludyga S, Gerber M, Brand S et al (2016) Acute effects of moderate aerobic exercise on specific aspects of executive function in different age and fitness groups: a meta-analysis. Psychophysiology 53(11):1611–1626. https://doi.org/10.1111/psyp.12736
Ludyga S, Gerber M, Puhse U et al (2020) Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals. Nat Hum Behav 4(6):603–612. https://doi.org/10.1038/s41562-020-0851-8
MacInnis MJ, Gibala MJ (2017) Physiological adaptations to interval training and the role of exercise intensity. J Physiol 595(9):2915–2930. https://doi.org/10.1113/jp273196
MacNeill SE, Lichtenberg PA (1997) Home alone: the role of cognition in return to independent living. Arch Phys Med Rehabil 78(7):755–758. https://doi.org/10.1016/s0003-9993(97)90085-x
Martinsen S, Flodin P, Berrebi J et al (2018) The role of long-term physical exercise on performance and brain activation during the stroop colour word task in fibromyalgia patients. Clin Physiol Funct Imaging 38(3):508–516. https://doi.org/10.1111/cpf.12449
Metcalfe AW, MacIntosh BJ, Scavone A et al (2016) Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder. Transl Psychiatry 6:e814. https://doi.org/10.1038/tp.2016.85
Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. PLoS Med 6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097
Montero-Odasso M, Verghese J, Beauchet O et al (2012) Gait and cognition: a complementary approach to understanding brain function and the risk of falling. J Am Geriatr Soc 60(11):2127–2136. https://doi.org/10.1111/j.1532-5415.2012.04209.x
Morris R, Lord S, Bunce J et al (2016) Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease. Neurosci Biobehav Rev 64:326–345. https://doi.org/10.1016/j.neubiorev.2016.02.012
Nishiguchi S, Yamada M, Tanigawa T et al (2015) A 12-week physical and cognitive exercise program can improve cognitive function and neural efficiency in community-dwelling older adults: a randomized controlled trial. J Am Geriatr Soc 63(7):1355–1363. https://doi.org/10.1111/jgs.13481
Northey JM, Cherbuin N, Pumpa KL et al (2018) Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br J Sports Med 52(3):154–160. https://doi.org/10.1136/bjsports-2016-096587
Oberste M, Javelle F, Sharma S et al (2019) Effects and moderators of acute aerobic exercise on subsequent interference control: a systematic review and meta-analysis. Front Psychol 10:2616. https://doi.org/10.3389/fpsyg.2019.02616
Park DC, Lautenschlager G, Hedden T et al (2002) Models of visuospatial and verbal memory across the adult life span. Psychol Aging 17(2):299–320
Park DC, Reuter-Lorenz P (2009) The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol 60:173–196. https://doi.org/10.1146/annurev.psych.59.103006.093656
Pensel MC, Daamen M, Scheef L et al (2018) Executive control processes are associated with individual fitness outcomes following regular exercise training: blood lactate profile curves and neuroimaging findings. Sci Rep 8(1):4893. https://doi.org/10.1038/s41598-018-23308-3
Piercy KL, Troiano RP, Ballard RM et al (2018) The physical activity guidelines for americans. JAMA 320(19):2020–2028. https://doi.org/10.1001/jama.2018.14854
Pontifex MB, McGowan AL, Chandler MC et al (2019) A primer on investigating the after effects of acute bouts of physical activity on cognition. Psychol Sport Exercise. 40:1–22. https://doi.org/10.1016/j.psychsport.2018.08.015
Power JD, Schlaggar BL, Lessov-Schlaggar CN et al (2013) Evidence for hubs in human functional brain networks. Neuron 79(4):798–813. https://doi.org/10.1016/j.neuron.2013.07.035
Reuter-Lorenz PA, Park DC (2014) How does it stac up? Revisiting the scaffolding theory of aging and cognition. Neuropsychol Rev 24(3):355–370. https://doi.org/10.1007/s11065-014-9270-9
Salthouse TA (2011) Neuroanatomical substrates of age-related cognitive decline. Psychol Bull 137(5):753–784. https://doi.org/10.1037/a0023262
Schmitt A, Martin JA, Rojas S et al (2019) Effects of low- and high-intensity exercise on emotional face processing: an fmri face-matching study. Soc Cogn Affect Neurosci 14(6):657–665. https://doi.org/10.1093/scan/nsz042
Sheffield JM, Repovs G, Harms MP et al (2015) Fronto-parietal and cingulo-opercular network integrity and cognition in health and schizophrenia. Neuropsychologia 73:82–93. https://doi.org/10.1016/j.neuropsychologia.2015.05.006
Shipley BA, Der G, Taylor MD et al (2006) Cognition and all-cause mortality across the entire adult age range: health and lifestyle survey. Psychosom Med 68(1):17–24. https://doi.org/10.1097/01.psy.0000195867.66643.0f
Smith JC, Nielson KA, Antuono P et al (2013) Semantic memory functional mri and cognitive function after exercise intervention in mild cognitive impairment. J Alzheimers Dis 37(1):197–215. https://doi.org/10.3233/jad-130467
Stillman CM, Cohen J, Lehman ME et al (2016) Mediators of physical activity on neurocognitive function: a review at multiple levels of analysis. Front Hum Neurosci 10:626. https://doi.org/10.3389/fnhum.2016.00626
Stillman CM, Esteban-Cornejo I, Brown B et al (2020) Effects of exercise on brain and cognition across age groups and health states. Trends Neurosci. https://doi.org/10.1016/j.tins.2020.04.010
Suwabe K, Byun K, Hyodo K et al (2018) Rapid stimulation of human dentate gyrus function with acute mild exercise. Proc Natl Acad Sci U S A 115(41):10487–10492. https://doi.org/10.1073/pnas.1805668115
Tulving E (1972) Episodic and semantic memory: organization of memory. Academic Press, Cambridge
Verburgh L, Konigs M, Scherder EJ et al (2014) Physical exercise and executive functions in preadolescent children, adolescents and young adults: a meta-analysis. Br J Sports Med 48(12):973–979. https://doi.org/10.1136/bjsports-2012-091441
Voelcker-Rehage C, Niemann C (2013) Structural and functional brain changes related to different types of physical activity across the life span. Neurosci Biobehav Rev. 37(9 Pt B):2268–2295. https://doi.org/10.1016/j.neubiorev.2013.01.028
Voss MW, Soto C, Yoo S et al (2019) Exercise and hippocampal memory systems. Trends Cogn Sci 23(4):318–333. https://doi.org/10.1016/j.tics.2019.01.006
Wagner G, Herbsleb M, de la Cruz F et al (2017) Changes in fmri activation in anterior hippocampus and motor cortex during memory retrieval after an intense exercise intervention. Biol Psychol 124:65–78. https://doi.org/10.1016/j.biopsycho.2017.01.003
Wriessnegger SC, Steyrl D, Koschutnig K et al (2014) Short time sports exercise boosts motor imagery patterns: Implications of mental practice in rehabilitation programs. Front Hum Neurosci 8:469. https://doi.org/10.3389/fnhum.2014.00469
Wu MT, Tang PF, Goh JOS et al (2018) Task-switching performance improvements after tai chi chuan training are associated with greater prefrontal activation in older adults. Front Aging Neurosci 10:280. https://doi.org/10.3389/fnagi.2018.00280
Xue Y, Yang Y, Huang T (2019) Effects of chronic exercise interventions on executive function among children and adolescents: a systematic review with meta-analysis. Br J Sports Med 53(22):1397–1404. https://doi.org/10.1136/bjsports-2018-099825
Yan CG, Wang XD, Zuo XN et al (2016) Dpabi: data processing & analysis for (resting-state) brain imaging. Neuroinformatics 14(3):339–351. https://doi.org/10.1007/s12021-016-9299-4
Yeo BTT, Krienen FM, Sepulcre J et al (2011) The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol 106(3):1125–1165. https://doi.org/10.1152/jn.00338.2011
Yu Q, Zou L, Kong Z et al (2020) Cognitive impact of calorie restriction: a narrative review. J Am Med Directors Assoc. https://doi.org/10.3390/brainsci9040087
Zhao W, Zimmermann K, Zhou X et al (2020) Impaired cognitive performance under psychosocial stress in cannabis- dependent men is associated with attenuated precuneus activity. J Psychiatry Neurosci 45(2):88–97. https://doi.org/10.1503/jpn.190039
Zheng G, Ye B, Zheng Y et al (2019) The effects of exercise on the structure of cognitive related brain regions: a meta-analysis of functional neuroimaging data. Int J Neurosci 129(4):406–415. https://doi.org/10.1080/00207454.2018.1508135
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Q.Y. and L.Y.Z. planned the meta-analysis and formulated the hypotheses. Q.Y. and L.Y.Z performed the literature search and screening. Q.YS., L.Y.Z and Y.J.Z conducted the data extraction and coding, calculated the effect sizes and rated the quality. Q.Y., B.K.B. and L.Y.Z performed the statistical analyses. Q.Y. F.H., and L.Y.Z drafted the initial version of the manuscript. All authors were involved in revisions of the draft.
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Yu, Q., Herold, F., Becker, B. et al. Cognitive benefits of exercise interventions: an fMRI activation likelihood estimation meta-analysis. Brain Struct Funct 226, 601–619 (2021). https://doi.org/10.1007/s00429-021-02247-2
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DOI: https://doi.org/10.1007/s00429-021-02247-2