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Reward-related dynamical coupling between basolateral amygdala and nucleus accumbens

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Abstract

Recognizing reward-related stimuli is crucial for survival. Neuronal projections from the basolateral amygdala (BLA) to the nucleus accumbens (NAc) play an important role in processing reward-related cues. Previous studies revealed synchronization between distant brain regions in reward-sensitive neurocircuits; however, whether the NAc synchronizes with the BLA is unknown. Here, we recorded local field potentials simultaneously from the BLA and NAc of rats during social preference tests and an appetitive conditioning test in which explicit stimuli were associated with food. BLA-NAc coherence in the theta band (5–8 Hz) increased in response to food-associated cues. Meanwhile, the modulatory strength of theta–high gamma (50–110 Hz) phase-amplitude cross-frequency coupling (PAC) in the NAc decreased. Importantly, both of these neuromodulations disappeared upon extinction. In contrast, both theta and gamma power oscillations in each region increased in the presence of social conspecifics or contexts associated with conspecifics, but coherence did not change. To potentially disrupt behavior and associated neural activity, a subgroup of rats was exposed prenatally to valproic acid (VPA), which has been shown to disrupt transcriptome and excitatory/inhibitory balance in the amygdala. VPA-exposed rats demonstrated impulsive-like behavior, but VPA did not affect BLA-NAc coherence. These findings reveal changes in BLA-NAc coherence in response to select reward-related stimuli (i.e., food-predictive cues); the differences between the tasks used here could shed light onto the functional nature of BLA-NAc coherence and are discussed.

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Acknowledgements

This work was supported by NIH P50 MH100023 and R01 DA044297. The Yerkes National Primate Research Center is supported by the Office of Research Infrastructure Programs/OD P51 OD011132.

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  1. Yerkes National Primate Research Center, Emory University, Atlanta, USA

    Chia-Chun Hsu, Teresa E. Madsen, Elizabeth O’Gorman, Shannon L. Gourley & Donald G. Rainnie

  2. Neuroscience Graduate Program, Emory University, Atlanta, USA

    Chia-Chun Hsu & Shannon L. Gourley

  3. Department of Pediatrics, Emory University, Atlanta, USA

    Chia-Chun Hsu & Shannon L. Gourley

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  1. Chia-Chun Hsu
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  2. Teresa E. Madsen
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Hsu, CC., Madsen, T.E., O’Gorman, E. et al. Reward-related dynamical coupling between basolateral amygdala and nucleus accumbens. Brain Struct Funct 225, 1873–1888 (2020). https://doi.org/10.1007/s00429-020-02099-2

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