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Anatomical predictors of cognitive decline after subthalamic stimulation in Parkinson’s disease

Brain Structure and Function volume 223, pages 3063–3072 (2018)Cite this article

Abstract

We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson’s disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who underwent bilateral STN-DBS. Normalized brain structure volumes and cortical thicknesses were measured on pre-operative T1-weighted MRI. Patients were tested for their cognitive performances before surgery and 1 year after. After controlling for age, gender, pre-operative disease severity, change in dopaminomimetic dose after surgery and contact location, we found correlations: (1) between the variation of the total Mattis dementia rating scale (MDRS) score and left lateral ventricle volume (p = 0.032), (2) between the variation of the initiation/perseveration subscore of the MDRS and the left nucleus accumbens volume (p = 0.042) and the left lateral ventricle volume (p = 0.017) and (3) between the variation of the backward digit-span task and the right and left superior frontal gyrus thickness (p = 0.004 and p = 0.007, respectively). Left nucleus accumbens atrophy was associated with decline in the initiation/perseveration subscore with the largest effect size (d = − 1.64). Pre-operative left nucleus accumbens volume strongly predicted postoperative decline in the initiation/attention subscore (AUC = 0.92, p < 0.001, 96.3% sensitivity, 80.0% specificity, 92.9% PPV and 92.9% NPV). We conclude that the morphometric measures of brain atrophy usually associated with cognitive impairment in PD can also explain or predict a part of cognitive decline after bilateral STN-DBS. In particular, the left accumbens nucleus volume could be considered as a promising marker for guiding surgical decisions.

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Acknowledgements

The authors want to thank Christine Delaigue, coordinating nurse for the Parkinson’s Disease Center in Clermont-Ferrand University Hospital. They also thank Prof. Thomas Tourdias and Prof. Vincent Dousset from Bordeaux University Hospital for making available their MRI analysis facilities, and Celine Lambert from Clermont-Ferrand University Hospital for her technical assistance.

Funding

Hospital Program for Clinical Research at Clermont-Ferrand University Hospital.

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Authors and Affiliations

  1. Service de Neurologie, CHU Clermont-Ferrand, Université Clermont Auvergne, 58 rue Montalembert, 63000, Clermont-Ferrand, France

    Vincent Planche, Philippe Derost, Bérangère Debilly, Ana Marques & Franck Durif

  2. Service de Neuroradiologie diagnostique et thérapeutique, CHU Bordeaux, Université Bordeaux, 33000, Bordeaux, France

    Fanny Munsch

  3. Unité de Biostatistiques, Direction à la Recherche Clinique et à l’Innovation (DRCI), CHU Clermont-Ferrand, 63000, Clermont-Ferrand, France

    Bruno Pereira & Dominique Morand

  4. Service de Neurochirurgie, CHU Clermont-Ferrand, Centre National de la Recherche Scientifique (CNRS), Université Clermont Auvergne, 63000, Clermont-Ferrand, France

    Emmanuel de Schlichting, Jerome Coste & Jean-Jacques Lemaire

  5. Centre Mémoire de Ressources et de Recherche (CMRR), CHU Clermont-Ferrand, 63000, Clermont-Ferrand, France

    Tiphaine Vidal

  6. Centre Médico-Psychologique B (CMP-B), CHU Clermont-Ferrand, Université Clermont Auvergne, 63000, Clermont-Ferrand, France

    Ingrid de Chazeron & Pierre-Michel Llorca

Authors
  1. Vincent Planche
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  2. Fanny Munsch
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  3. Bruno Pereira
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  4. Emmanuel de Schlichting
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  5. Tiphaine Vidal
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  8. Ingrid de Chazeron
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  9. Philippe Derost
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  12. Jean-Jacques Lemaire
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  13. Ana Marques
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  14. Franck Durif
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Contributions

Conception of the project: VP and FD. Organization: FD. Execution: all authors. Statistical Analysis: VP and BP. Writing of the first draft: VP. Review and Critique: all authors. Study concept and design: VP, BP, JJL and FD.

Corresponding author

Correspondence to Vincent Planche.

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Conflict of interest

VP received travel expenses and/or consulting fees from the ARSEP Foundation, Biogen, Teva-Lundbeck and Merk-Serono, unrelated to the submitted work. FD serves on scientific advisory boards and has received honoraria and research support for his institution from Novartis, Teva-Lundbeck, Allergan, Aguettant, Servier and Merz, unrelated to the submitted work. Other authors: no conflict of interests.

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Planche, V., Munsch, F., Pereira, B. et al. Anatomical predictors of cognitive decline after subthalamic stimulation in Parkinson’s disease. Brain Struct Funct 223, 3063–3072 (2018). https://doi.org/10.1007/s00429-018-1677-2

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  • DOI: https://doi.org/10.1007/s00429-018-1677-2

Keywords

  • Parkinson’s disease
  • Deep-brain stimulation
  • Subthalamic nucleus
  • Nucleus accumbens
  • MRI
  • Cognition