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Brain Structure and Function

, Volume 223, Issue 4, pp 1637–1666 | Cite as

Receptor-driven, multimodal mapping of the human amygdala

  • Olga Kedo
  • Karl Zilles
  • Nicola Palomero-Gallagher
  • Axel Schleicher
  • Hartmut Mohlberg
  • Sebastian Bludau
  • Katrin Amunts
Original Article

Abstract

The human amygdala consists of subdivisions contributing to various functions. However, principles of structural organization at the cellular and molecular level are not well understood. Thus, we re-analyzed the cytoarchitecture of the amygdala and generated cytoarchitectonic probabilistic maps of ten subdivisions in stereotaxic space based on novel workflows and mapping tools. This parcellation was then used as a basis for analyzing the receptor expression for 15 receptor types. Receptor fingerprints, i.e., the characteristic balance between densities of all receptor types, were generated in each subdivision to comprehensively visualize differences and similarities in receptor architecture between the subdivisions. Fingerprints of the central and medial nuclei and the anterior amygdaloid area were highly similar. Fingerprints of the lateral, basolateral and basomedial nuclei were also similar to each other, while those of the remaining nuclei were distinct in shape. Similarities were further investigated by a hierarchical cluster analysis: a two-cluster solution subdivided the phylogenetically older part (central, medial nuclei, anterior amygdaloid area) from the remaining parts of the amygdala. A more fine-grained three-cluster solution replicated our previous parcellation including a laterobasal, superficial and centromedial group. Furthermore, it helped to better characterize the paralaminar nucleus with a molecular organization in-between the laterobasal and the superficial group. The multimodal cyto- and receptor-architectonic analysis of the human amygdala provides new insights into its microstructural organization, intersubject variability, localization in stereotaxic space and principles of receptor-based neurochemical differences.

Keywords

Amygdala Cytoarchitecture Probabilistic mapping Receptor architecture Human brain 

Notes

Acknowlegdments

We would like to thank Markus Cremer, Sabine Wilms, Stephanie Krause, Angelika Börner, Jessica Teske-Bausch and René Hübbers for their excellent technical assistance.

Compliance with ethical standards

Funding

This project has received funding from the European Union's Horizon 2020 Framework Programme for Research and Innovation under Grant Agreement No 720270 (Human Brain Project SGA1).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Olga Kedo
    • 1
  • Karl Zilles
    • 1
    • 2
    • 3
  • Nicola Palomero-Gallagher
    • 1
  • Axel Schleicher
    • 1
  • Hartmut Mohlberg
    • 1
  • Sebastian Bludau
    • 1
  • Katrin Amunts
    • 1
    • 3
    • 4
  1. 1.Institute of Neuroscience and Medicine, INM-1Research Centre JülichJülichGermany
  2. 2.Department of Psychiatry, Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenGermany
  3. 3.JARA-BRAINJülich-Aachen Research AllianceAachenGermany
  4. 4.C. & O. Vogt Institute for Brain ResearchUniversity Hospital Düsseldorf, Heinrich Heine University DüsseldorfDüsseldorfGermany

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