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Retrograde transneuronal degeneration in the retina and lateral geniculate nucleus of the V1-lesioned marmoset monkey

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Abstract

Retrograde transneuronal degeneration (RTD) of retinal ganglion cells and dorsal lateral geniculate (LGN) neurons are well described following a lesion of the primary visual cortex (V1) in both Old World monkeys and humans. Based on previous studies of New World monkeys and prosimians, it was suggested that these species displayed no RTD following a lesion of V1. In this study of the New World marmoset monkey, 1 year after a unilateral V1 lesion either in adults or at 14 days after birth, we observed ~20 % ganglion cell (GC) loss in adult but ~70 % in infants. This finding is similar to the RTD previously described for Old World Macaca monkeys. Furthermore, in infants we find a similar amount of RTD at 3 weeks and 1 year following lesion, demonstrating that RTD is very rapid in neonates. This highlights the importance of trying to prevent the rapid onset of RTD following a lesion of V1 in early life as a strategy for improved functional recovery. Despite differences in GC loss, there was little difference between LGN degeneration in infant versus adult lesions. A wedge on the horizontal meridian corresponding to the LGN foveal representation revealed extensive neuronal loss. Retinal afferent input was labeled by cholera toxin B subunit. Input to the degenerated parvocellular layers was difficult to detect, while input to magnocellular and koniocellular layers was reduced but still apparent. Our demonstration that the New World marmoset monkey shares many of the features of neuroplasticity with Old World Macaca monkeys and humans emphasizes the opportunity and benefit of marmosets as models of visual cortical injury.

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Acknowledgments

National Health and Medical Research Council Project Grants (APP1002049 and APP1042893) supported this work. The Australian Regenerative Medicine Institute is supported by grants from the State Government of Victoria and the Australian Government.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Washington, Box 358058, Seattle, WA, 98109, USA

    A. Hendrickson, D. Possin & J. Huang

  2. Australian Regenerative Medicine Institute, Monash University, Level 1, Building 75, Clayton, VIC, 3800, Australia

    C. E. Warner, W. C. Kwan & J. A. Bourne

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  1. A. Hendrickson
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  2. C. E. Warner
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  3. D. Possin
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  4. J. Huang
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  5. W. C. Kwan
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  6. J. A. Bourne
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Correspondence to J. A. Bourne.

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Hendrickson, A., Warner, C.E., Possin, D. et al. Retrograde transneuronal degeneration in the retina and lateral geniculate nucleus of the V1-lesioned marmoset monkey. Brain Struct Funct 220, 351–360 (2015). https://doi.org/10.1007/s00429-013-0659-7

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