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Paternal deprivation alters the development of catecholaminergic innervation in the prefrontal cortex and related limbic brain regions

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Abstract

The impact of paternal care on the development of catecholaminergic fiber innervations in the prefrontal cortex, nucleus accumbens, hippocampus and the amygdala was quantitatively investigated in the biparental Octodon degus. Two age (juvenile, adult) and rearing groups: (1) degus reared without father and (2) degus raised by both parents were compared. Juvenile father-deprived animals showed significantly elevated densities of TH-immunoreactive fibers in all analyzed regions, except in the orbitofrontal cortex, as compared to biparentally reared animals. This difference between the two rearing groups was still evident in adulthood in the prelimbic and infralimbic cortices and in the hippocampal formation. Interestingly, the elevated TH fiber density in both nucleus accumbens subregions was reversed in adulthood, i.e. adult father-deprived animals showed strongly reduced TH fiber densities as compared to biparentally reared animals. We show here that paternal care plays a critical role in the functional maturation of catecholaminergic innervation patterns in prefrontal and limbic brain circuits.

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Abbreviations

Acb:

Nucleus accumbens

AcbC:

Nucleus accumbens, core region

AcbSh:

Nucleus accumbens, shell region

ACd:

Anterior cingulate cortex

BLA:

Basolateral amygdala

CA1:

CA3 subregions of the hippocampal formation

CeA:

Nucleus of the central amygdala

DG:

Dentate gyrus

LO:

Lateral orbitofrontal cortex

OFC:

Orbitofrontal cortex

P:

Postnatal day

PL/IL:

Prelimbic/infralimbic prefrontal cortex

TH:

Tyrosine hydroxylase

VO:

Ventral orbitofrontal cortex

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Acknowledgments

This research was supported by grants from the German-Israeli Foundation (Grant #101/2011), the Center of Brain and Behavioral Sciences (CBBS), the European Regional Development Fund (ERDF) and a postgraduate fellowship from the state of Saxony-Anhalt to K. S.

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Authors and Affiliations

  1. Department of Zoology/Developmental Neurobiology, Institute for Biology, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany

    Katharina Braun, Katja Seidel & Nicole Groeger

  2. Center for Behavioral Brain Science (CBBS), Magdeburg, Germany

    Katharina Braun

  3. Department of Human Biology, Institute for Biology, University of Leipzig, 04103, Leipzig, Germany

    Romy Holetschka & Gerd Poeggel

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  1. Katharina Braun
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  2. Katja Seidel
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  3. Romy Holetschka
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  4. Nicole Groeger
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  5. Gerd Poeggel
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Correspondence to Katharina Braun.

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K. Braun and K. Seidel contributed equally to the work.

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Braun, K., Seidel, K., Holetschka, R. et al. Paternal deprivation alters the development of catecholaminergic innervation in the prefrontal cortex and related limbic brain regions. Brain Struct Funct 218, 859–872 (2013). https://doi.org/10.1007/s00429-012-0434-1

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