Brain Structure and Function

, Volume 214, Issue 2–3, pp 263–283 | Cite as

Understanding the molecular basis of Alzheimer’s disease using a Caenorhabditis elegans model system

  • Collin Y. Ewald
  • Chris Li


Alzheimer’s disease (AD) is the major cause of dementia in the United States. At the cellular level, the brains of AD patients are characterized by extracellular dense plaques and intracellular neurofibrillary tangles whose major components are the β-amyloid peptide and tau, respectively. The β-amyloid peptide is a cleavage product of the amyloid precursor protein (APP); mutations in APP have been correlated with a small number of cases of familial Alzheimer’s disease. APP is the canonical member of the APP family, whose functions remain unclear. The nematode Caenorhabditis elegans, one of the premier genetic workhorses, is being used in a variety of ways to address the functions of APP and determine how the β-amyloid peptide and tau can induce toxicity. First, the function of the C. elegans APP-related gene, apl-1, is being examined. Although different organisms may use APP and related proteins, such as APL-1, in different functional contexts, the pathways in which they function and the molecules with which they interact are usually conserved. Second, components of the γ-secretase complex and their respective functions are being revealed through genetic analyses in C. elegans. Third, to address questions of toxicity, onset of degeneration, and protective mechanisms, different human β-amyloid peptide and tau variants are being introduced into C. elegans and the resultant transgenic lines examined. Here, we summarize how a simple system such as C. elegans can be used as a model to understand APP function and suppression of β-amyloid peptide and tau toxicity in higher organisms.


Model system C. elegans apl-1 Presenilins Beta amyloid Tau 



We wish to thank Casey Brander for help with the figures and lab members for helpful discussions. This work was supported by grants from the Alzheimer’s Association, National Institutes Health, and National Science Foundation (CL) and a National Institutes of Health RCMI grant to City College.


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© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Graduate Center and Department of BiologyCity College of the City University of New YorkNew YorkUSA
  2. 2.Department of BiologyCity College of New YorkNew YorkUSA

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