Abstract
The topological changes of the human autonomic cardiac nervous system in two cadavers with a retroesophageal right subclavian artery (Rersa) were compared with the normal autonomic cardiac nervous system. The following new results were obtained in addition to the conventional deficient finding of the right recurrent laryngeal nerve. (1) Right superior cardiac nerves arising from the superior cervical ganglion were consistently observed in both cadavers, in addition to the right thoracic cardiac nerves along the Rersa. (2) A segmental accompanying tendency of the right cardiac nerves was recognized: the cardiac nerves arising from the sympathetic trunk cranial to the middle cervical ganglia ran along with the right common carotid artery, whereas the cardiac nerves arising from the sympathetic trunk caudal to the vertebral ganglion ran along the Rersa. (3) The right thoracic cardiac nerves, which have never been observed to accompany the normal right subclavian artery, ran along the proximal part of the Rersa. According to previous reports of individuals with the Rersa, a thick right thoracic cardiac nerve is commonly observed instead of a right superior cardiac nerve. However, all the cardiac nerves were recognized in both the individuals described in the present report. Therefore, we strongly disagree with the previous idea that the origin of the right cardiac nerves from the sympathetic trunk and ganglia is shifted caudally in individuals with the Rersa. The topological changes of the autonomic cardiac nervous system in two cases of Rersa also reflected spatial changes of great arteries.
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References
Aizawa Y, Isogai S, Izumiyama M, Horiguchi M (1999) Morphogenesis of the primary arterial trunks of the forelimb in the rat embryo: the trunks originate from the lateral surface of the dorsal aorta independently of the intersegmental arteries. Anat Embryol 200:573–584
Bergwerff M, DeRuiter MC, Hall S, Poelmann RE, Gittenberge-de Groot AC (1999) Unique vascular morphology of the fourth aortic arches: possible implications for pathogenesis of type-B aortic arch interruption and anomalous right subclavian artery. Cardiovasc Res 44:185–196
Chiba S, Suzuki T, Kasai T (1981) Two cases of the right subclavian artery as last branch of the aortic arch and review of previously reported cases (in Japanese with English abstract). Hirosaki Med 33:465–474
Congdon ED (1922) Transformation of the aortic-arch system during the development of the human embryo. Carnegie Inst Contr Embryol 68:47–110
Hiruma T, Nakajima Y, Nakamura H (2002) Development of pharyngeal arch arteries in early mouse embryo. J Anat 201:15–29
Horiguchi M, Yamada T, Uchiyama Y (1982) A case of retroesophageal right subclavian artery with special reference to the morphology of cardiac nerves (in Japanese with English abstract). Acta Anat Nippon 57:1–8
Jakubowicz M, Ratajczak W, Nowik M (2002) Aberrant left subclavian artery. Folia Morphol 61:53–56
Kawashima T (2005) The autonomic nervous system of the human heart with special reference to the origin, course, and peripheral distribution of the nerve. Anat Embryol 209:425–438
Kitchell RL, Stevens CE, Turbes CC (1957) Cardiac and aortic arch anomalies, hydrocephalus, and other abnormalities in newborn pig. J Am Vet Med Assoc 130:453–457
Kumaki K (1980) Anatomical practice data (in Japanese). Second Department of Anatomy, School of Medicine, Kanazawa University, Kanazawa
Kuntz A, Morehouse A (1930) Thoracic cardiac nerves in man. Arch Surg 20:607–613
Kurt MA, Ari I, Ikiz I (1997) A case with coincidence of aberrant right subclavian artery and common origin of the carotid arteries. Ann Anat 179:175–176
Larsen WJ (2001) Human embryology, 3rd edn. Churchill Livingstone, New York, pp 197–204
Loukas M, Giannikopoulos P, Fudalej M, Dimopoulos C, Wagner T (2004) Aretroesophageal right subclavian artery originating from the left aortic arch—a case report and review of the literature. Folia Morphol 63:141–145
Mitchell GAG (1953) Anatomy of the autonomic nervous system. ES Livingstone, London
Molin DGM, DeRuiter MC, Wisse LJ, Azhar M, Doetschman T, Poelmann RE, Gittenberge-de Groot AC (2002) Altered apoptosis pattern during pharyngeal arch artery remodeling is associated with aortic arch malformations in Tgfß2 knock-out mice. Cardiovasc Res 56:312–322
Moore KL, Persaud TVN (1998) The developing human. Clinically oriented embryology, 6th.edn. WB Saunders, Philadelphia, pp 384–391
Nakatani T, Tanaka S, Mizukami S, Okamoto K, Shiraishi Y, Nakamura T (1996) Retroesophageal right subclavian artery originating from the aortic arch distal and dorsal to the left subclavian artery. Ann Anat 178:269–271
Okishima T, Ohdo S, Takamura K, Hayakawa K (1987) Morphogenesis of an aberrant subclavian artery in rat embryos after maternal treatment of bis-diamine (in Japanese with English abstract). Jpn J Pediatr 91:859–869
Patten BM (1968) Human embryology, 3rd edn. McGraw Hill, New York, pp 509–514
Saccomanno G (1943) The components of the upper thoracic sympathetic nerves. J Comp Neurol 79:355–378
Sadler TW (2004) Langman’s medical embryology, 9th edn. Lippincott Williams & Wilkins, Philadelphia
Shimada K, Shibata M, Tanaka J, Setoyama S, Suzuki M, Ito J (1997) A rare variation of the right subclavian artery combined with a variation of the right vertebral artery (in Japanese with English abstract). Showa Med 57:349–353
Sumida H (1988) Study of abnormal formation of the aortic arch in rats: by methacrylate casts method and by immunohistochemistry for appearance and distribution of desmin, myosin and fibronectin in the tunica media. Hiroshima J Med Sci 37:19–36
Suzuki T, Chiba S, Takahashi D, Kasai T (1990) Morphological considerations of the bronchial arteries and cardiac nerves, in the so-called Adachi’s type-G aortic arch (in Japanese with English abstract). Hirosaki Med 42:176–182
Tanaka S (2000) Vagal cardiac branches. In: Sato T, Akita K (ed) Anatomic variations in Japanese (in Japanese). University of Tokyo Press, Tokyo, pp 513–516
Tasaka H, Takenaka H, Okamoto N, Onitsuka T, Koga Y, Hamada M (1991) Abnormal development of cardiovascular system in rat embryos treated with bisdiamine. Teratology 43:191–200
Wilson JG, Warkany J (1949) Aortic-arch and cardiac anomalies in the offspring of vitamin A deficient rats. Am J Anat 85:113–155
Wilson JG, Warkany J (1950) Cardiac and aortic arch anomalies in the offspring of vitamin A deficient rats correlated with similar human anomalies. Pediatrics 5:708–725
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This study was supported by grants from the Japan Foundation of Cardiovascular Research 2003 and Scientific Research from the Ministry of Education, Culture, Sports Science and Technology (no. 16790804).
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Kawashima, T., Sasaki, H. Topological changes of the human autonomic cardiac nervous system in individuals with a retroesophageal right subclavian artery: two case reports and a brief review. Anat Embryol 210, 327–334 (2005). https://doi.org/10.1007/s00429-005-0052-2
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DOI: https://doi.org/10.1007/s00429-005-0052-2