Abstract
In breast carcinomas the TP53 gene is altered in 10–30% of cases. Alteration of the gene may lead to a general genomic instability, detected as deletions and/or amplifications at the gene level, and as altered expression at the mRNA and protein level. We have demonstrated a strong association between down-regulation of E-cadherin protein expression and alterations of the p53 protein, detected as TP53 gene mutation and/or protein accumulation in tumour samples from 210 patients with breast carcinomas (P <0.001). Investigation of allelic imbalance using microsatellite markers located near the E-cadherin locus was also performed. A higher frequency of loss of heterozygosity in the microsatellite marker closest to the E-cadherin locus was observed in samples with down-regulation of E-cadherin protein expression. A higher frequency of down-regulation of the E-cadherin protein expression was found in invasive lobular carcinomas than in invasive ductal carcinomas, although this difference was of borderline significant (P=0.084). Cases in the present series were also immunostained for c-erbB-2 protein overexpression. A significant association between p53 protein accumulation and cerbB-2 protein overexpression was seen (P=0.036). The results of the present study indicate that p53 protein may play a role in regulation of E-cadherin protein expression.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 29 May 1997)Accepted: 10 June 1997
Rights and permissions
About this article
Cite this article
Bukholm, I., Nesland, J., Kåresen, R. et al. Expression of E-cadherin and its relation to the p53 protein status in human breast carcinomas. Virchows Archiv 431, 317–321 (1997). https://doi.org/10.1007/s004280050105
Issue Date:
DOI: https://doi.org/10.1007/s004280050105