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Gastric mesenchymal tumor with gastroblastoma-like features harboring PTCH1::GLI2 fusion

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Fig. 1
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Data availability

The datasets generated and/or analyzed in the current study are available from the corresponding author upon reasonable request.

References

  1. Miettinen M, Dow N, Lasota J, Sobin LH (2009) A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young adults (‘gastroblastoma’): a series of 3 cases. Am J Surg Pathol 33:1370–1377. https://doi.org/10.1097/pas.0b013e3181a6a792

    Article  PubMed  Google Scholar 

  2. Graham RP, Nair AA, Davila JI et al (2017) Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene. Mod Pathol 30:1443–1452. https://doi.org/10.1038/modpathol.2017.68

    Article  CAS  PubMed  Google Scholar 

  3. Castri F, Ravegnini G, Lodoli C et al (2019) Gastroblastoma in old age. Histopathology 75:778–782. https://doi.org/10.1111/his.13951

    Article  PubMed  Google Scholar 

  4. Shabbir J, Earle J, Glomski K, Mnayer L, Schipper B, Ligato S (2024) Gastroblastoma with a novel ACTB::GLI1 gene fusion in a 19-year-old male. Virchows Arch Epub ahead of print. https://doi.org/10.1007/s00428-024-03742-7

  5. Chen C, Lu J, Wu H (2022) Case report: submucosal gastroblastoma with a novel PTCH1::GLI2 gene fusion in a 58-year-old man. Front Oncol 12:935914. https://doi.org/10.3389/fonc.2022.935914

    Article  PubMed  PubMed Central  Google Scholar 

  6. Liu Y, Wu H, Wu X et al (2022) Gastroblastoma treated by endoscopic submucosal excavation with a novel PTCH1::GLI2 fusion: rare case report and literature review. Curr Oncol 29:8862–8873. https://doi.org/10.3390/curroncol29110697

    Article  PubMed  PubMed Central  Google Scholar 

  7. Koo SC, LaHaye S, Kovari BP et al (2021) Gastroblastoma with a novel EWSR1-CTBP1 fusion presenting in adolescence. Gene Chromosome Cancer 60:640–646. https://doi.org/10.1002/gcc.22973

    Article  CAS  Google Scholar 

  8. Dahlén A, Fletcher CDM, Mertens F et al (2004) Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12). Am J Pathol 164:1645–1653. https://doi.org/10.1016/S0002-9440(10)63723-6

    Article  PubMed  PubMed Central  Google Scholar 

  9. Papke DJ Jr, Dickson BC, Oliveira AM, Sholl LM, Fletcher CDM (2023) Distinctive nested glomoid neoplasm: clinicopathologic analysis of 20 cases of a mesenchymal neoplasm with frequent GLI1 alterations and indolent behavior. Am J Surg Pathol 47:12–24. https://doi.org/10.1097/PAS.0000000000001979

    Article  PubMed  Google Scholar 

  10. Liu J, Mao R, Lao IW et al (2022) GLI1-altered mesenchymal tumor: a clinicopathological and molecular analysis of ten additional cases of an emerging entity. Virchows Arch 480:1087–1099. https://doi.org/10.1007/s00428-021-03224-0

    Article  CAS  PubMed  Google Scholar 

  11. Cloutier JM, Kerr DA (2024) GLI1-altered mesenchymal tumors. Surg Pathol Clin 17:13–24. https://doi.org/10.1016/j.path.2023.06.004

    Article  PubMed  Google Scholar 

  12. Jessurun J, Orr C, McNulty SN et al (2023) GLI1-rearranged enteric tumor: expanding the spectrum of gastrointestinal neoplasms with GLI1 gene fusions. Am J Surg Pathol 47:65–73. https://doi.org/10.1097/PAS.0000000000001950

    Article  PubMed  Google Scholar 

  13. Castro E, Cortes-Santiago N, Ferguson LM, Rao PH, Venkatramani R, López-Terrada D (2016) Translocation t(7;12) as the sole chromosomal abnormality resulting in ACTB-GLI1 fusion in pediatric gastric pericytoma. Hum Pathol 53:137–141. https://doi.org/10.1016/j.humpath.2016.02.015

    Article  CAS  PubMed  Google Scholar 

  14. Kim SH, Da Cruz PA, Basili T et al (2020) Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary. Nat Commun 11:44. https://doi.org/10.1038/s41467-019-13806-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW (2016) Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors. Cancers (Basel) 8:22. https://doi.org/10.3390/cancers8020022

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We are grateful to Kazunari Tanabe, Kaoruko Kojima, Namiko Kondo, and Ayumi Sumiishi for their technical assistance and Alvin P. Makohon-Moore for language proofreading.

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Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine, Kyorin University, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan

    Takahiro Shibayama, Akimasa Hayashi, Kaishi Satomi & Junji Shibahara

  2. Department of Gastroenterological and General Surgery, Faculty of Medicine, Kyorin University, Tokyo, Japan

    Nobutsugu Abe & Atsuko Ohki

Authors
  1. Takahiro Shibayama
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  2. Akimasa Hayashi
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  3. Nobutsugu Abe
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  4. Atsuko Ohki
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  5. Kaishi Satomi
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  6. Junji Shibahara
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Contributions

Conceptualization: Takahiro Shibayama, Akimasa Hayashi, and Junji Shibahara. Methodology, formal analysis, investigation, and original draft preparation: Takahiro Shibayama, Akimasa Hayashi, Nobutsugu Abe, Atsuko Ohki, Kaishi Satomi, and Junji Shibahara. Drafting or critical revision of the article: Takahiro Shibayama, Akimasa Hayashi, and Junji Shibahara. All the authors have read and approved the final version of the manuscript.

Corresponding author

Correspondence to Takahiro Shibayama.

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Shibayama, T., Hayashi, A., Abe, N. et al. Gastric mesenchymal tumor with gastroblastoma-like features harboring PTCH1::GLI2 fusion. Virchows Arch (2024). https://doi.org/10.1007/s00428-024-03812-w

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