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Solitary fibrous tumours involving the genitourinary tract: a case series in rare locations, highlighting the role of STAT6 immunohistochemistry

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Abstract

Solitary fibrous tumour (SFT) is a mesenchymal neoplasm with variable behaviour, very rarely involving the genitourinary (GU) tract. Most reported cases correspond to isolated case reports. STAT6 immunohistochemistry is a more recent and reliable diagnostic marker. The pathology database of two tertiary institutes was searched for SFTs involving the GU tract. STAT6 strong diffuse nuclear staining confirmed the diagnosis in all four cases, and the NAB2::STAT6 fusion was demonstrated by NGS in one case. Two cases were diagnosed in needle biopsy, one involving the prostate and the other involving the seminal vesicle. One case corresponded to a pelvic mass inseparable from and infiltrating the prostate and bladder. The remainder represented an exceedingly rare involvement of the spermatic cord. Involvement by a SFT should be considered in the differential diagnosis of spindle cell lesions involving GU organs. STAT6 strong diffuse nuclear staining is an important ancillary tool, particularly in a biopsy.

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Authors and Affiliations

  1. Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal

    João Lobo

  2. Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) & RISE@CI-IPOP (Health Research Network), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal

    João Lobo

  3. Department of Pathology and Molecular Immunology, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-513, Porto, Portugal

    João Lobo

  4. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA

    Lara R Harik

  5. Department of Urology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA

    Charles C Peyton

  6. Instituto D’Or de Pesquisa e Ensino (IDOR), São Paulo, Brazil

    Mariana Andozia Morini

  7. Department of Pathology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, AL, USA

    Bassel Zein-Sabatto, Thomas Winokur, Valeria Dal Zotto & Cristina Magi-Galluzzi

Authors
  1. João Lobo
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  2. Lara R Harik
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  3. Charles C Peyton
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  4. Mariana Andozia Morini
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  5. Bassel Zein-Sabatto
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  6. Thomas Winokur
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  7. Valeria Dal Zotto
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  8. Cristina Magi-Galluzzi
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Contributions

Writing — drafting manuscript: JL. Methodology: JL, LH, CCP, MM, BZS, TW, VDZ. Writing — critical revision of draft: CMG. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to João Lobo or Cristina Magi-Galluzzi.

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All procedures were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Only archival material was used.

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The authors declare no competing interests.

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Lobo, J., Harik, L.R., Peyton, C.C. et al. Solitary fibrous tumours involving the genitourinary tract: a case series in rare locations, highlighting the role of STAT6 immunohistochemistry. Virchows Arch 484, 697–702 (2024). https://doi.org/10.1007/s00428-023-03694-4

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  • DOI: https://doi.org/10.1007/s00428-023-03694-4

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