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Frequent nuclear β-catenin expression in pulmonary enteric-type adenocarcinoma according to the current World Health Organization criteria

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Abstract

Based on the current World Health Organization classification criteria, five of 3895 consecutive cases of surgically resected primary lung carcinomas (0.13%) categorized as enteric-type were analyzed. Three cases completely comprised tumor cells that resemble colorectal adenocarcinoma, while the other two cases exhibited features of conventional adenocarcinomas admixed with enteric components. Immunohistochemically, all patients expressed at least three of the five intestinal markers: CDX2, CK20, HNF4α, MUC2, and SATB2. None of the patients expressed TTF-1 and NKX3.1. Three cases showed nuclear accumulation of β-catenin, indicating activation of the Wnt/β-catenin signaling pathway; APC mutations were detected in one of these cases. TP53 mutations were detected in three cases. Mutated EGFR or ALK fusions were not detected. Our study demonstrates that pulmonary enteric-type adenocarcinomas share immunohistochemical features and genetic alterations with colorectal adenocarcinomas, which are characterized by frequent activation of the Wnt/β-catenin signaling pathway and a lack of actionable mutations.

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Data availability

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy and ethical restrictions.

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Acknowledgements

This work was performed in part at the Intractable Disease Research Center, Juntendo University.

Funding

This study was partly supported by grants by the Grant-in-Aid for Japan Society for the Promotion of Science (JSPS) KAKENHI (Grant Number #22K15416 and 22H02842).

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Authors and Affiliations

  1. Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan

    Satsuki Kishikawa, Takuo Hayashi, Ayako Ura, Noriko Sasahara, Tsuyoshi Saito & Takashi Yao

  2. Department of General Thoracic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-Ku, Tokyo, 113-8421, Japan

    Kazuya Takamochi & Kenji Suzuki

Authors
  1. Satsuki Kishikawa
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  2. Takuo Hayashi
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  3. Kazuya Takamochi
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  4. Ayako Ura
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  5. Noriko Sasahara
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  6. Tsuyoshi Saito
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  7. Kenji Suzuki
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  8. Takashi Yao
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on behalf of the Tokyo Metropolitan Innovative oncology research Group (TMIG)

Contributions

Satsuki Kishikawa, Takuo Hayashi, Ayako Ura, Noriko Sasahara, Tsuyoshi Saito, and Takashi Yao provided histopathological and immunohistochemical information. Kazuya Takamochi and Kenji Suzuki provided clinical information on the patient. Satsuki Kishikawa, Takuo Hayashi, and Tsuyoshi Saito conceived the molecular experiments and analyzed the data. All authors were involved in writing the paper and provided final approval of the submitted and published versions.

Corresponding author

Correspondence to Takuo Hayashi.

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The authors declare no competing interests.

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Kishikawa, S., Hayashi, T., Takamochi, K. et al. Frequent nuclear β-catenin expression in pulmonary enteric-type adenocarcinoma according to the current World Health Organization criteria. Virchows Arch 483, 699–703 (2023). https://doi.org/10.1007/s00428-023-03657-9

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  • DOI: https://doi.org/10.1007/s00428-023-03657-9

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