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Adenosquamous carcinoma in situ of the anus: a case series

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Abstract

While human papillomavirus (HPV)-associated adenocarcinoma of the anus resembling endocervical adenocarcinoma has recently been described, anal adenocarcinoma in situ/AIS has not. Moreover, to the best of our knowledge, truly biphasic anal adenosquamous carcinoma in situ (ADSQ-IS) is essentially non-existent in the literature. Here, we report four cases of anal ADSQ-IS including one with associated invasive adenosquamous carcinoma. Histologically, all cases of ADSQ-IS showed a basal/peripheral population of stratified, p40-positive dysplastic squamous cells adjacent to luminal, columnar, p40-negative dysplastic glandular cells, bearing a striking resemblance to the normal anal transitional epithelium. Both lesional components were diffusely and strongly positive for p16 and positive for high-risk HPV by RNA in situ hybridization. These cases expand the morphological spectrum of high-risk HPV-associated pre-invasive lesions and underscore the plasticity of HPV-associated neoplasia.

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Data sharing is not applicable to this article, as no datasets were generated or analyzed during the current study.

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Funding

This work was supported by the Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA

    Aysenur Keske, Paul S. Weisman & Jin Xu

Authors
  1. Aysenur Keske
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  2. Paul S. Weisman
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  3. Jin Xu
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Contributions

Aysenur Keske: investigation, methodology. Paul Weisman: conceptualization, investigation, and writing. Jin Xu: conceptualization, methodology, investigation, supervision, and writing.

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Correspondence to Paul S. Weisman.

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This study was approved by the authors’ institutional review board.

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The authors declare no competing interests.

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Keske, A., Weisman, P.S. & Xu, J. Adenosquamous carcinoma in situ of the anus: a case series. Virchows Arch 482, 993–997 (2023). https://doi.org/10.1007/s00428-023-03525-6

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  • DOI: https://doi.org/10.1007/s00428-023-03525-6

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