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Mesonephric-like adenocarcinoma of the ovary with squamoid morular metaplasia, aberrant β-catenin expression, and concurrent FGFR2 and CTNNB1 mutations: a case report

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A LETTER TO THE EDITOR to this article was published on 30 September 2023

Abstract

In general, endometrioid-defining features such as squamoid morular metaplasia are not thought to be associated with mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA). Here, we report a case of FGFR2-mutated ovarian MLA with squamoid morular metaplasia accompanied by aberrant nuclear and cytoplasmic β-catenin expression and CTNNB1 mutation. Histologically, the tumor showed classical MLA histology, including well-formed glands with intraluminal eosinophilic secretions and cells with papillary thyroid carcinoma-like nuclei. Squamoid morular metaplasia was intimately associated with the tumor. Glandular epithelial elements, including those immediately associated with the squamoid morules, were negative for ER, but positive for both GATA3 and PAX8; aberrant β-catenin expression was limited to the squamoid morules. This case illustrates the ability of mesonephric neoplasia to exhibit histological features previously thought to be restricted to an endometrioid phenotype.

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Data sharing is not applicable to this article, as no datasets were generated or analyzed during the current study.

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Funding

This work was supported by the Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA. This study was also funded in part by the NIH/NCI Support Grant P30 CA008748 for Memorial Sloan Kettering Cancer Center.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Jin Xu, William M. Rehrauer & Paul S. Weisman

  2. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Kay J. Park

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  1. Jin Xu
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  2. Kay J. Park
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  3. William M. Rehrauer
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  4. Paul S. Weisman
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Contributions

Dr. Jin Xu is principally responsible for the conceptual design, slide review, and data analysis and participated in manuscript writing and review. Dr. Kay Park was involved in the review and revision of the manuscript. Dr. William Rehrauer performed the next-generation DNA sequencing and data analysis. Dr. Paul Weisman provided the conceptual design, slide review, data analysis, and manuscript writing steps of this study.

Corresponding author

Correspondence to Jin Xu.

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Ethics approval

This study was approved by the authors’ institutional review board. This study was approved by the UW-Madison Research Ethics Board under protocol UW18144 with IRB#2018–1510 at UW-Madison in Madison, WI, USA.

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The authors declare no competing interests.

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Xu, J., Park, K.J., Rehrauer, W.M. et al. Mesonephric-like adenocarcinoma of the ovary with squamoid morular metaplasia, aberrant β-catenin expression, and concurrent FGFR2 and CTNNB1 mutations: a case report. Virchows Arch 484, 147–150 (2024). https://doi.org/10.1007/s00428-023-03522-9

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  • DOI: https://doi.org/10.1007/s00428-023-03522-9

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