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SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix

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Abstract

Neuroendocrine carcinoma (NEC) of the uterine cervix is less characterized than neuroendocrine neoplasms of other sites such as of the digestive system and the lung. Special AT-rich sequence-binding protein 2 (SATB2) recently emerged as a marker of well-differentiated neuroendocrine tumors of the lower gastrointestinal (GI) tract. Among NECs, SATB2 is more frequently expressed in cutaneous Merkel cell carcinoma than in NEC of other anatomical sites. In our study, we performed an immunohistochemical study of SATB2 in 16 NECs of the uterine cervix, where the expression of these markers is still undefined. SATB2 was expressed in 12/16 cervical NECs (75%), with 7/16 cases (44%) showing SATB2 positivity in ≥ 50% of cells. In 7 cervical NECs associated with a non-neuroendocrine component, the expression of SATB2 was restricted to the neuroendocrine component. SATB2 was positive in all cases that expressed CDX2 (n = 7) and TTF1 (n = 5), with no evident association with p16 and p53. Our study demonstrated that SATB2 is often expressed in NECs of the uterine cervix. This information should be taken into account when assessing the origin of a NEC.

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Authors and Affiliations

  1. Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168, Rome, Italy

    Frediano Inzani, Giuseppe Angelico, Angela Santoro, Antonio Travaglino, Damiano Arciuolo, Giulia Scaglione, Nicoletta D’Alessandris, Michele Valente & Gian Franco Zannoni

  2. ENETS Center of Excellence, Neuroendocrine Tumor (NET) Center, Rome, Italy

    Frediano Inzani & Guido Rindi

  3. Pathology Unit, Department of Advanced Biomedical Sciences, School of Medicine, University of Naples Federico II, Naples, Italy

    Antonio Travaglino & Luigi Insabato

  4. Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy

    Antonio Raffone

  5. Section of Anatomic Pathology, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00100, Rome, Italy

    Angela Carlino & Guido Rindi

  6. Catholic University of Sacred Heart, Rome, Italy

    Guido Rindi & Gian Franco Zannoni

  7. Department of Woman and Child Health, UCSC, and Fondazione Policlinico Gemelli, Rome, Italy

    Gian Franco Zannoni

Authors
  1. Frediano Inzani
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  2. Giuseppe Angelico
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  3. Angela Santoro
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  4. Antonio Travaglino
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  5. Luigi Insabato
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  6. Antonio Raffone
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  7. Damiano Arciuolo
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  8. Giulia Scaglione
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  9. Nicoletta D’Alessandris
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  10. Michele Valente
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  11. Angela Carlino
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  12. Guido Rindi
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  13. Gian Franco Zannoni
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Contributions

FI, GFZ, and GR: study design and acquisition of pathological data. AS, GA, and AC: acquisition of pathological data and writing of the manuscript. AT, LI, and AR: acquisition of clinical data and surgical procedures. VM and GS: performed the histological examination and revised the paper critically for important intellectual content. DA and ND: critical review of the manuscript. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Gian Franco Zannoni.

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Ethics approval

The Institutional Review Board (IRB) of Fondazione Policlinico A. Gemelli—IRCCS—considered the retrospective nature of the study and approved the submission of our scientific work (N. Prot. 19640/20).

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The authors declare no competing interests.

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Inzani, F., Angelico, G., Santoro, A. et al. SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix. Virchows Arch 480, 873–877 (2022). https://doi.org/10.1007/s00428-021-03255-7

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  • DOI: https://doi.org/10.1007/s00428-021-03255-7

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