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Indolent T-lymphoblastic proliferation: a report of three cases

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Abstract

Indolent T-lymphoblastic proliferation (iT-LBP) is the extrathymic proliferation of nonclonal TdT + T cells and is typically associated with lymphoid disorders. Although one study revealed that iT-LBP occurred in angioimmunoblastic T-cell lymphoma, no other lymphoma-related cases have been reported. Here, we report three cases of concurrent iT-LBP and benign or malignant lymphoid disorders. The first patient had bilateral cervical lymph node enlargement, and the resected lymph node showed polyclonal precursor T-cells distributed between benign hyperplastic lymphoid follicles. In the second case, iT-LBP occurred in peripheral T-cell lymphoma with a follicular growth pattern, showing that precursor T-cells were distributed between neoplastic follicles composed of CD4 + and CXCL13 + T-cells. In the third case, polyclonal precursor T-cells were distributed between the neoplastic follicles of follicular lymphoma. In summary, our results indicate an association between iT-LBP and reactive lymphoid hyperplasia (case 1) and lymphoma (cases 2 and 3).

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Authors and Affiliations

  1. Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China

    Zheng Yuanyuan, Xie Jianlan, Zhang Yanlin & Zhou Xiaoge

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  1. Zheng Yuanyuan
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  2. Xie Jianlan
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  3. Zhang Yanlin
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  4. Zhou Xiaoge
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Contributions

Zhou Xiaoge designed the study. Zheng Yuanyuan wrote the manuscript. Xie Jianlan and Zhang Yanlin prepared tissue sections and performed Immunohistochemical staining and polymerase chain reaction testing.

Corresponding author

Correspondence to Zhou Xiaoge.

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All patients provided written informed consent for use of tissue samples for research and were audited by the Medical Ethics Committee of Beijing Friendship Hospital, Capital Medical University (approval number 2020-P2-137–01).

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The authors declare no competing interests.

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Yuanyuan, Z., Jianlan, X., Yanlin, Z. et al. Indolent T-lymphoblastic proliferation: a report of three cases. Virchows Arch 480, 1121–1126 (2022). https://doi.org/10.1007/s00428-021-03184-5

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  • DOI: https://doi.org/10.1007/s00428-021-03184-5

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