Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera
Pure erythroid leukemia (PEL) is an uncommon subtype of acute myeloid leukemia (AML) [7, 8, 13, 15]. While AML is recognized as a complication of polycythemia vera (PV) [10, 11, 12], there are few reports of PV transformation to PEL [1, 2, 3, 4, 6, 8, 9]. Five reported cases of PEL arising from PV, diagnosed between 1956 and 1962, followed therapy with radioactive phosphorus (32P) [1, 4, 6, 9]. There were two case reports of transformation following therapy with hydroxyurea, in 1998 and 2012 [2, 3]. More recently, transformation to PEL and erythroid sarcoma in patients with long-standing PV treated with phlebotomy and hydroxyurea was described . Here, we report molecular evidence of an unusual case of PEL with osseous involvement arising in a patient with known JAK2 V617F-positive PV.
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Conflict of interest
The authors declare that they have no conflict of interest.
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