Duodenal histological features in suspected non-celiac gluten sensitivity: new insights into a still undefined condition
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Since the late seventies, when gluten-related disorders were first described, up to nowadays, non-celiac gluten sensitivity or non-celiac wheat sensitivity (NCGS/NCWS) is still a not well-defined clinical entity.
Epidemiological data are inconsistent providing a wide range of prevalence from 0.5 to 13% in Western countries . The clinical spectrum of this condition is characterized by the presence, in different association, of gastrointestinal (especially bloating and abdominal pain/discomfort with or without alteration in bowel movement) and extra-intestinal symptoms (fatigue, headache, joint pain, foggy mind, and so forth) with a wide overlap of its presentation with irritable bowel syndrome (IBS), other functional gastrointestinal disorders, and other organic etiologies such as bacterial or parasitic infections, autoimmune disorders, and inflammatory bowel diseases (IBD).
In June 2015, Salerno Experts’ criteria were published with the proposal of a double (or...
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