Decidual granulomatous reaction in a placenta from a preeclamptic pregnancy: a case report and review of the literature

  • Simon B. Chen
  • Satoru Kudose
  • Hannah R. Krigman
Brief Report


We report a case of decidual perivascular non-necrotizing granulomas in a placenta from a pregnancy complicated by severe preeclampsia with no evidence of infection. The mother was a 20-year-old primigravida with severe preeclampsia diagnosed in the third trimester with subsequent delivery of a healthy baby boy at 37 weeks 5 days gestation. Pathologic examination of the placenta showed scattered non-necrotizing granulomas in decidua, often adjacent to remodeled decidual arteries without fibrinoid necrosis. These were well-formed, non-necrotizing granulomas with scant lymphoid cuffs. Polarization microscopy did not show foreign material. There were no histopathologic or clinical findings suggestive of maternal-fetal infection or systemic vasculitis at the time of delivery, and the mother had no other reported conditions associated with granulomatous inflammation. Our case demonstrates that granulomatous reaction may be seen in the placenta from a pregnancy complicated by severe preeclampsia, although work-up for infection may be indicated.


Decidua Granuloma Placenta Preeclampsia 


Compliance with ethical standards

The manuscript is an original work of all authors. All authors made a significant contribution to this study, including acquisition, analysis, and interpretation of data, as well as drafting and critical revision of work for important intellectual content. All authors have read and approved the final version of the manuscript. All authors have no conflict of interest to declare. All authors agree to be accountable for all aspects of the work in ensuring that questions pertaining to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The manuscript is a retrospective case report that does not require ethics committee approval.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Simon B. Chen
    • 1
  • Satoru Kudose
    • 2
  • Hannah R. Krigman
    • 2
  1. 1.Department of PathologyStanford University Medical CenterStanfordUSA
  2. 2.Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA

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