Skip to main content
SpringerLink
Log in

Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product

  • Brief Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

The pathogenesis of benign-looking cartilaginous tissue within the peritoneum is unknown. Chondroid metaplasia of subcoelomic mesenchyme has been suggested, as has been the case for other gynecological diseases such as endometriosis, peritoneal leiomyomatosis, or gliomatosis peritonei, but has never been proven. Chondroid nodules in the peritoneum may represent either teratomatous tissue, fetal rests from a conception product, or metaplasia of pluripotent mesenchymal cells. Herein, the unique genetic characteristics of ovarian teratomas (homozygous at many polymorphic microsatellite loci) versus normal tissues (heterozygous at the same loci) were used to investigate the origin of chondroid nodules in the peritoneum. DNA samples extracted from paraffin-embedded normal peritoneal tissue and chondroid peritoneal nodules from two patients were studied. In both cases, chondroid and normal tissue showed heterozygosity at each informative microsatellite locus on different chromosomes, with a profile similar to the mother. These results indicate that peritoneal chondroid nodules arise within the peritoneum, presumably from pluripotent mesodermal stem cells, and are not related to teratomatous proliferation, or previous pregnancy. This finding shows once again the plasticity and metaplastic potential of stem cells within the peritoneal cavity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Giardino L, Savoldi E, Pontieri F, Piattelli A, Tallarigo F (2006) Chondroid metaplasia in inflamed pulp tissue: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e42–e45

    Article  PubMed  Google Scholar 

  2. Kohl SK, Simpson RJ, Wisecarver J (2009) Chondroid metaplasia mimicking recurrent squamous cell carcinoma of the head and neck. Ear Nose Throat J 88:E4

    PubMed  Google Scholar 

  3. Boukas A, Joshi A, Jenkins A, Holliman D (2013) Extensive cartilaginous metaplasia of recurrent posterior fossa ependymoma: case report and review of the literature. Pediatr Neurosurg 49:93–98

    Article  PubMed  Google Scholar 

  4. Bedrosian SA, Goldman RL, Sung MA (1983) Heterotopic cartilage in prostate. Urology 21:536–537

    Article  PubMed  CAS  Google Scholar 

  5. Roth E, Taylor HB (1966) Heterotopic cartilage in the uterus. Obstet Gynecol 27:838–844

    PubMed  CAS  Google Scholar 

  6. Fadare O, Bifulco C, Carter D, Parkash V (2002) Cartilaginous differentiation in peritoneal tissues: a report of two cases and a review of the literature. Mod Pathol 15:777–780

    Article  PubMed  Google Scholar 

  7. Vortmeyer AO, Devouassoux-Shisheboran M, Li G, Mohr V, Tavassoli F, Zhuang Z (1999) Microdissection-based analysis of mature ovarian teratoma. Am J Pathol 154:987–991

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Scully RE, Young RH, Clement PB (1998) Mucinous tumors in: tumors of the ovary and maldeveloped gonads, fallopian tubes and broad ligament. In: Atlas of tumor pathology, 3rd edn. AFIP, Washington DC, pp 81–105

    Google Scholar 

  9. Hegde P (2014) Extragonadal omental teratoma: a case report. J Obstet Gynaecol Res 40:618–621

    Article  PubMed  Google Scholar 

  10. Ferguson AW, Katabuchi H, Ronnett BM, Cho KR (2001) Glial implants in gliomatosis peritonei arise from normal tissue, not from the associated teratoma. Am J Pathol 159:51–55

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Donna A, Betta PG, Bianchi V et al (1991) A new insight into the histogenesis of ‘mesodermomas’--malignant mesotheliomas. Histopathology 19:239–244

    Article  PubMed  CAS  Google Scholar 

  12. Jakubowitz O (1925) Beitrag zur klinik und histologie der adenomyosis (adenomyohyperplasie) uteri interna; berlin: Inaug Diss

  13. Houang M, Merkur H, Russell P (2010) Chondroid metaplasia of the peritoneum. Pathology 42:585–587

    Article  PubMed  Google Scholar 

  14. Mutsaers SE, Birnie K, Lansley S, Herrick SE, Lim C-B, Prêle CM (2015) Mesothelial cells in tissue repair and fibrosis. Front Pharmacol 6:113

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Patel RM, Weiss SW, Folpe AL (2006) Heterotopic mesenteric ossification: a distinctive pseudosarcoma commonly associated with intestinal obstruction. Am J Surg Pathol 30:119–122

    Article  PubMed  Google Scholar 

  16. Qasem SA, DeYoung BR (2014) Cartilage-forming tumors. Semin Diagn Pathol 31:10–20

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hospices Civils de Lyon, Department of Pathology, Centre de Biologie et de Pathologie Sud, Chemin du Grand Revoyet, 69495, Pierre Bénite Cedex, France

    Tatiana Franceschi, Fabienne Allias, Claire Mauduit & Mojgan Devouassoux-Shisheboran

  2. Department of Gynecological Surgery and Oncology, Obstetrics, 165 chemin du Grand Revoyet, 69495, Pierre Bénite Cedex, France

    Pierre-Adrien Bolze

Authors
  1. Tatiana Franceschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fabienne Allias
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claire Mauduit
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pierre-Adrien Bolze
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mojgan Devouassoux-Shisheboran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mojgan Devouassoux-Shisheboran.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Electronic supplementary material

ESM 1

(GIF 95 kb)

High Resolution Image

(TIFF 4688 kb)

ESM 2

(GIF 96 kb)

High Resolution Image

(TIFF 4917 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Franceschi, T., Allias, F., Mauduit, C. et al. Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product. Virchows Arch 473, 115–119 (2018). https://doi.org/10.1007/s00428-018-2295-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-018-2295-3

Keywords

Search

Navigation