References
Demunter A et al (2002) Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations. Mod Pathol 15(4):454–461
MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17(1):9–26
Lazar AJ et al (2008) Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol 173(5):1518–1527
Omholt K et al (2001) Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer 92(6):839–842
Pollock PM, Hayward N (2002) Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines. Melanoma Res 12(2):183–186
Reifenberger J et al (2002) Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. Int J Cancer 100(5):549–556
Gallagher SJ et al (2013) Beta-catenin inhibits melanocyte migration but induces melanoma metastasis. Oncogene 32(17):2230–2238
Rubinfeld B et al (1997) Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 275(5307):1790–1792
van Engen-van Grunsven AC et al (2014) Update on molecular pathology of cutaneous melanocytic lesions: what is new in diagnosis and molecular testing for treatment? Front Med (Lausanne) 1:39
Blokx WA, van Dijk MC, Ruiter DJ (2010) Molecular cytogenetics of cutaneous melanocytic lesions—diagnostic, prognostic and therapeutic aspects. Histopathology 56(1):121–132
Yeh I et al (2017) Combined activation of MAP kinase pathway and beta-catenin signaling cause deep penetrating nevi. Nat Commun 8(1):644
Eijkelenboom A et al (2016) Reliable next-generation sequencing of formalin-fixed, paraffin-embedded tissue using single molecule tags. J Mol Diagn 18(6):851–863
Luzar B, Calonje E (2011) Deep penetrating nevus: a review. Arch Pathol Lab Med 135(3):321–326
Strazzula L et al (2014) The deep penetrating nevus. J Am Acad Dermatol 71(6):1234–1240
Robson A et al (2003) Deep penetrating naevus: clinicopathological study of 31 cases with further delineation of histological features allowing distinction from other pigmented benign melanocytic lesions and melanoma. Histopathology 43(6):529–537
Funding
There was no funding involved.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent
Both patients signed an informed consent form.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Teunissen, B.T., Knuiman, G.J., Eijkelenboom, A. et al. CTNNB1-mutated melanocytic lesions with DPN like features: a distinct subtype of melanocytic tumors? A report of two cases. Virchows Arch 472, 683–687 (2018). https://doi.org/10.1007/s00428-017-2250-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00428-017-2250-8