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Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience

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References

  1. Speight PM, Barrett AW (2002) Salivary gland tumours. Oral Dis 8:229–240

    Article  CAS  PubMed  Google Scholar 

  2. Adenoid cystic carcinoma (2017). In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of tumors of the head and neck, 4th ed. Tumors of salivary glands. Lyon:IARC Press; 164–165

  3. Bell D, Hanna EY (2013) Head and neck adenoid cystic carcinoma: what is new in biological markers and treatment? Curr Opin Otolaryngol Head Neck Surg 21:124–129

    Article  PubMed  Google Scholar 

  4. Barsky SH, Karlin NJ (2005) Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia 10:249–260

    Article  PubMed  Google Scholar 

  5. Hu M, Yao J, Carroll DK et al (2008) Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 13:394–406

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bell D, Bell AH, Bondaruk J, Hanna EY, Weber RS (2016) In-depth characterization of the salivary adenoid cystic carcinoma transcriptome with emphasis on dominant cell type. Cancer 122:1513–1522

    Article  CAS  PubMed  Google Scholar 

  7. Bell D, Roberts D, Karpowicz M, Hanna EY, Weber RS, El-Naggar AK (2011) Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 12:569–573

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bell D, Roberts D, Kies M, Rao P, Weber RS, El-Naggar AK (2010) Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer 116:5749–5756

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lloyd S, JB Y, Wilson LD, Decker RH (2011) Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiation therapy. Am J Clin Oncol 34:76–81

    Article  PubMed  Google Scholar 

  10. Hu Z, Fan C, DS O et al (2006) The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7:96

    Article  PubMed  PubMed Central  Google Scholar 

  11. Perou CM, Sorlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747–752

    Article  CAS  PubMed  Google Scholar 

  12. Prat A, Perou CM (2011) Deconstructing the molecular portraits of breast cancer. Mol Oncol 5:5–23

    Article  CAS  PubMed  Google Scholar 

  13. Raouf A, Zhao Y, To K et al (2008) Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell 3:109–118

    Article  CAS  PubMed  Google Scholar 

  14. Weigelt B, Hu Z, He X et al (2005) Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res 65:9155–9158

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by MD Anderson start-up funds (DB).

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Correspondence to Diana Bell.

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The authors declare that they have no conflict of interest.

Ethical approval

This retrospective, single-institution study was approved by MD Anderson’s Institutional Review Board.

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Hanna, E.Y., Abdelmeguid, A.S.A., Roberts, D. et al. Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience. Virchows Arch 472, 505–512 (2018). https://doi.org/10.1007/s00428-017-2248-2

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  • DOI: https://doi.org/10.1007/s00428-017-2248-2

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