Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience
Adenoid cystic carcinoma (ACC) is a biphasic salivary gland malignancy that is characterized by cellular, morphologic, and clinical heterogeneity . ACCs are the second most common salivary gland malignancy, are the most common malignancy of minor salivary glands, and comprise 15–25% of all salivary carcinomas. Despite locally aggressive growth with frequent perineural invasion, ACCs demonstrate slow biologic progression and lymph node metastasis is rare .
ACC arises from the intercalated ducts, which are composed of inner ductal epithelial and outer myoepithelial cell . The histogenesis of these tumors is uncertain, and an origin from stem cells with multidirectional differentiation is likely possible. Histologic architecture alone determines the grade of ACC; tubular and cribriform growth patterns are associated with a longer survival time than solid forms are [1, 2, 3]. Myoepithelial cells may play a role in restraining the aggressive biological behavior of...
This work was supported by MD Anderson start-up funds (DB).
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Conflict of interest
The authors declare that they have no conflict of interest.
This retrospective, single-institution study was approved by MD Anderson’s Institutional Review Board.
- 2.Adenoid cystic carcinoma (2017). In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of tumors of the head and neck, 4th ed. Tumors of salivary glands. Lyon:IARC Press; 164–165Google Scholar