Virchows Archiv

, Volume 472, Issue 3, pp 505–512 | Cite as

Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience

  • Ehab Y. Hanna
  • Ahmed S. A. Abdelmeguid
  • Dianna Roberts
  • Achim H. Bell
  • Randal S. Weber
  • Diana Bell
Brief Report


Adenoid cystic carcinoma (ACC) is a biphasic salivary gland malignancy that is characterized by cellular, morphologic, and clinical heterogeneity [1]. ACCs are the second most common salivary gland malignancy, are the most common malignancy of minor salivary glands, and comprise 15–25% of all salivary carcinomas. Despite locally aggressive growth with frequent perineural invasion, ACCs demonstrate slow biologic progression and lymph node metastasis is rare [1].

ACC arises from the intercalated ducts, which are composed of inner ductal epithelial and outer myoepithelial cell [2]. The histogenesis of these tumors is uncertain, and an origin from stem cells with multidirectional differentiation is likely possible. Histologic architecture alone determines the grade of ACC; tubular and cribriform growth patterns are associated with a longer survival time than solid forms are [1, 2, 3]. Myoepithelial cells may play a role in restraining the aggressive biological behavior of...



This work was supported by MD Anderson start-up funds (DB).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This retrospective, single-institution study was approved by MD Anderson’s Institutional Review Board.


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Copyright information

© Springer-Verlag GmbH Deutschland 2017

Authors and Affiliations

  1. 1.Department of Head and Neck SurgeryThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of PathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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