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Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary

Virchows Archiv volume 470, pages 225–229 (2017)Cite this article

Abstract

Microcystic stromal tumors (MCST), first described in 2009 by Irving et al., are rare ovarian neoplasms. The entity was introduced into the 2014 WHO classification of tumors of female reproductive organs in the group of sex cord-stromal tumors, which is rather heterogeneous. We studied three cases of ovarian tumor with the characteristic morphological features and immunohistochemical marker profiles of MCST. The three tumors showed micro, and macrocystic patterns with solid areas, and were composed of small round to spindle-shaped cells, without atypia. The tumors diffusely and strongly expressed CD10, FOXL2, and nuclear β-catenin, but without immmunoreactivity for hormone receptors, calretinin, or inhibin. Genome analyses showed no somatic mutation of exon 1 of the FOXL2 gene and of exons 24 and 25 of DICER1 gene, the latter not having been reported previously. The patients are well, without evidence of tumor progression 1 to 10 years after diagnosis.

The absence of FOXL2 and DICER1 gene mutation, along with strong FOXL2 immunoreactivity provides additional evidence to place MCST within pure gonadal stromal rather than sex cord ovarian tumors.

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Affiliations

  1. Department of Pathology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Université Lyon I, 165 Chemin du Grand Revoyet, 69310, Pierre-Bénite, France

    Alexandra Meurgey & Mojgan Devouassoux-Shisheboran

  2. Department of Molecular Biology, Hospices Civils de Lyon, Centre hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69310, Pierre-Bénite, France

    Françoise Descotes

  3. Departement of Pathology, Institut Universitaire du Cancer Toulouse, Oncopole 1 Avenue Irène Jolliot-Curie Cedex 9, 31059, Toulouse, France

    Eliane Mery-Lamarche

Authors
  1. Alexandra Meurgey
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  2. Françoise Descotes
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  3. Eliane Mery-Lamarche
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  4. Mojgan Devouassoux-Shisheboran
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Corresponding author

Correspondence to Mojgan Devouassoux-Shisheboran.

Ethics declarations

This study was conducted according to the rules of Declaration of Helsinki and the Ethics Committee of the Medical Board (CHU Lyon) agreed to these investigations. Consent for genetic investigations, was obtained from the three patients.

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There is no funding for this study.

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The authors declare that they have no conflict of interest.

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Meurgey, A., Descotes, F., Mery-Lamarche, E. et al. Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary. Virchows Arch 470, 225–229 (2017). https://doi.org/10.1007/s00428-016-2038-2

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  • DOI: https://doi.org/10.1007/s00428-016-2038-2

Keywords

  • Microcystic stromal tumor
  • DICER1
  • FOXL2
  • Sex-cord stromal tumors
  • Ovary