Skip to main content
SpringerLink
Log in

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

  • Case Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Banerjee SS, Harris M (2000) Morphological and immunophenotypic variations in malignant melanoma. Histopathology 36(5):387–402

    Article  PubMed  CAS  Google Scholar 

  2. Breza TS, Magro CM (2005) CD34 expression in primary cutaneous malignant melanoma: apropos of a case and review of the aberrant melanoma phenotype. J Cutan Pathol 32(10):685–689

    Article  PubMed  Google Scholar 

  3. Lee H, Torres FX, McLean SA, Chen R, Lee MW (2011) Immunophenotypic heterogeneity of primary sinonasal melanoma with aberrant expression of neuroendocrine markers and calponin. Appl Immunohistochem Mol Morphol 19(1):48–53

    Article  PubMed  CAS  Google Scholar 

  4. Magro CM, Crowson AN, Mihm MC (2006) Unusual variants of malignant melanoma. Mod Pathol 19:S41–S70

    Article  PubMed  Google Scholar 

  5. Plaza JA, Suster D, Perez-Montiel D (2007) Expression of immunohistochemical markers in primary and metastatic malignant melanoma: a comparative study in 70 patients using a tissue microarray technique. Appl Immunohistochem Mol Morphol 15(4):421–425

    Article  PubMed  CAS  Google Scholar 

  6. Solus JF, Kraft S (2013) Ras, Raf, and MAP kinase in melanoma. Adv Anat Pathol 20(4):217–226

    Article  PubMed  CAS  Google Scholar 

  7. Miller DD, Emley A, Yang S, Richards JE, Lee JE, Deng A, Hoang MP, Mahalingam M (2012) Mixed versus pure variants of desmoplastic melanoma: a genetic and immunohistochemical appraisal. Mod Pathol 25(4):505–515

    Article  PubMed  CAS  Google Scholar 

  8. Whiteman DC, Pavan WJ, Bastian BC (2011) The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res 24(5):879–897

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Dahl C, Guldberg P (2007) The genome and epigenome of malignant melanoma. APMIS 115(10):1161–1176

    Article  PubMed  CAS  Google Scholar 

  10. Kusters-Vandevelde HV, Klaasen A, Küsters B et al (2010) Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system. Acta Neuropathol 119(3):317–323

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  11. Rikhof B, van Doorn J, Suurmeijer AJ et al (2009) Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour. Ann Oncol 20(9):1582–1588

    Article  PubMed  CAS  Google Scholar 

  12. Barnett SL, Wells MJ, Mickey B, Hatanpaa KJ (2011) Perineural extension of cutaneous desmoplastic melanoma mimicking an intracranial malignant peripheral nerve sheath tumor. Case report. J Neurosurg 115(2):273–277

    Article  PubMed  Google Scholar 

  13. Idriss MH, De Jesús G, McClain SA, Gottlieb GJ (2013) Melanoma masquerading as xanthogranuloma: a diagnostic pitfall. Am J Dermatopathol 35(3):e41–e44

    Article  PubMed  Google Scholar 

  14. Kontozis L, Sotoriou M et al (2011) Isolated right atrial metastasis of malignant melanoma mimicking a myxoma. Hell J Cardiol 52(3):281–284

    Google Scholar 

  15. Lehmer LM, Raqsdale BD, Frost MV, Ferguson KL (2011) Large neglected ulcerated melanoma mimicking extramedullary plasmacytoma. Am J Dermatopathol 33(8):e94–e98

    Article  PubMed  Google Scholar 

  16. Ordonez NG (2013) Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update. Hum Pathol. doi:10.1016/j.humpath.2013.02.007

    Google Scholar 

  17. Schneider M, Höltje J, Kehler U, Hartmann V, Holl-Ullrich K, Oechel K, Urban PP (2013) Malignant perivascular melanoma mimicking primary central nervous system vasculitis. J Neurol 260(2):680–684

    Article  PubMed  Google Scholar 

  18. Sidiropoulos M, Syro LV, Rotondo F et al (2013) Melanoma of the sellar region mimicking pituitary adenoma. Neuropathology 33(2):175–178

    Article  PubMed  Google Scholar 

  19. Tsuchihashi H, Ito A, Tsukada H, Hasegawa H, Naitoh H, Hanasawa K, Okada K (2011) A case of amelanotic anorectal malignant melanoma mimicking gastrointestinal stromal tumor. Gan To Kagaku Ryoho 38(13):2659–2662

    PubMed  Google Scholar 

  20. Hoang MP, Selim MP, Bentley RC, Burchette JL, Shea CR (2001) CD34 expression in desmoplastic melanoma. J Cutan Pathol 28(10):508–512

    Article  PubMed  CAS  Google Scholar 

  21. Zelger BG, Steiner H, Wambacher B, Zelger B (1997) Malignant melanomas simulating various types of soft tissue tumors. Dermatol Surg 23(11):1047–1054

    Article  PubMed  CAS  Google Scholar 

  22. Greaves WO, Verma S, Patel KP, Davies MA, Barkoh BA, Galbincea JM, Yao H, Lazar AJ, Aldape KD, Medeiros LJ, Luthra R (2013) Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma. J Mol Diagn 15(2):220–226

    Article  PubMed  CAS  Google Scholar 

  23. Dearden S, Stevens J, Wu JL, Blowers D (2013) Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap). Ann Oncol 24(9):2371–2376

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  24. Kleinschmidt-DeMasters BK, Aisner DL, Birks DK, Foreman NK (2013) Epithelioid GBMs show a high percentage of BRAF V600E mutation. Am J Surg Pathol 37(5):685–698

    Article  PubMed  Google Scholar 

  25. Ohashi K, Sequist LV, Arcila ME et al (2013) Characteristics of lung cancers harboring NRAS mutations. Clin Cancer Res 19(9):2584–2591

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  26. Sinicrope FA, Smyrk TC, Tougeron D et al (2013) Mutation-specific antibody detects mutant BRAF protein expression in human colon carcinomas. Cancer 119(15):2765–2770

    Article  PubMed  CAS  Google Scholar 

  27. Vaughn CP, Zobell SD, Furtado LV, Baker CL, Samowitz WS (2011) Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer. Gene Chromosome Cancer 50(5):307–312

    Article  CAS  Google Scholar 

  28. Robinson DR, Wu YM, Kalyana-Sundaram S et al (2013) Identification of recurrent NAB2–STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet 45(2):180–185

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  29. Blokx WA, Lesterhuis WJ, Andriessen MP, Verdijk MA, Punt CJ, Ligtenberg MJ (2007) CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma. Am J Surg Pathol 31(4):637–641

    Article  PubMed  Google Scholar 

  30. Kusters-Vandevelde HV, Keunen JE, Wesseling P, Verdijk MA, Ligtenberg MJ, Blokx WA (2008) Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis. Virchows Arch 452(3):331–336

    Article  PubMed  Google Scholar 

  31. Box NF, Terzian T (2008) The role of p53 in pigmentation, tanning and melanoma. Pigment Cell Melanoma Res 21(5):525–533

    Article  PubMed  CAS  Google Scholar 

  32. Colombino M, Capone M, Lissia A et al (2012) BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J Clin Oncol 30(20):2522–2529

    Article  PubMed  Google Scholar 

  33. Gast A, Scherer D, Chen B et al (2010) Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study. Gene Chromosome Canc 49(8):733–745

    Article  CAS  Google Scholar 

  34. Giglia-Mari G, Sarasin A (2003) TP53 mutations in human skin cancers. Hum Mutat 21(3):217–228

    Article  PubMed  CAS  Google Scholar 

  35. Piccinin S, Doglioni C, Maestro R, Vukosavljevic T, Gasparotto D, D’Orazi C, Boiocchi M (1997) p16/CDKN2 and CDK4 gene mutations in sporadic melanoma development and progression. Int J Cancer 74(1):26–30

    Article  PubMed  CAS  Google Scholar 

  36. Soto JL, Carbrera CM, Serrano S, López-NEvot MA (2005) Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2B. BMC Cancer 5:36

    Article  PubMed Central  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Elise M. Bekers, Adriana C. H. van Engen-van Grunsven, Patricia J. T. A. Groenen, Harm Westdorp, Rutger H. T. Koornstra, Johannes J. Bonenkamp, Uta Flucke & Willeke A. M. Blokx

Authors
  1. Elise M. Bekers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adriana C. H. van Engen-van Grunsven
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patricia J. T. A. Groenen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Harm Westdorp
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rutger H. T. Koornstra
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Johannes J. Bonenkamp
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Uta Flucke
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Willeke A. M. Blokx
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elise M. Bekers.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bekers, E.M., van Engen-van Grunsven, A.C.H., Groenen, P.J.T.A. et al. Metastatic melanoma mimicking solitary fibrous tumor: report of two cases. Virchows Arch 464, 247–251 (2014). https://doi.org/10.1007/s00428-014-1542-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-014-1542-5

Keywords

Search

Navigation