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Expression of Krűppel-like factor 5 in gastric cancer and its clinical correlation in Taiwan

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Abstract

Krűppel-like factors (KLFs), highly conserved zinc-finger proteins, play either anti- or pro-proliferation roles in different human cancers through regulating a wide range of genes’ expression. Here, we investigated the expression of KLF5 in gastric cancers and its correlation with clinicopathological parameters and overall survival rates. In this study, KLF5 expression was measured by an immunohistochemical microarray assay of tissue taken from 76 surgical specimens. Higher KLF5 expression was significantly associated with lower tumor grade (P < 0.001). Nuclear staining of the KLF5 expression was significantly associated with a higher tumor grade (P = 0.000), higher clinical stage (P = 0.019), lymph node status (P = 0.016), and 2-year survival (P = 0.017). Patients with nuclear staining of KLF5 had a significantly lower disease-free survival rate compared to patients with negative nuclear staining, as defined by a log-rank test (P = 0.041). Our results revealed that KLF5 may play an oncogenetic role in gastric carcinogenesis.

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Acknowledgment

This work was supported by grant 99-CCH-IRP-09 from Changhua Christian Hospital and grants from National Science Council (NSC-94-2311-B-040-002 and NSC-93-2311-B-040-009), Taiwan.

Conflict of interest

We declare that we did not have conflict of interest.

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan

    Maw-Soan Soon

  2. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan

    Li-Sung Hsu

  3. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, 402, Taiwan

    Li-Sung Hsu

  4. Institute of Medicine, Chung Shan Medical University, Taichuang, Taiwan

    Chih-Jung Chen

  5. Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichuang, Taiwan

    Chih-Jung Chen

  6. Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan

    Chih-Jung Chen

  7. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan

    Chih-Jung Chen

  8. Department of Pathology, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua, Taiwan

    Pei-Yi Chu, Jia-Hung Liou, Shu-Hui Lin & Kun-Tu Yeh

  9. Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan

    Pei-Yi Chu

  10. Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Jeng-Dong Hsu & Kun-Tu Yeh

  11. Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Kun-Tu Yeh

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  1. Maw-Soan Soon
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  2. Li-Sung Hsu
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  7. Jeng-Dong Hsu
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Corresponding author

Correspondence to Kun-Tu Yeh.

Additional information

Maw-Soan Soon and Li-Sung Hsu contribute equally to this research as the first authors.

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Soon, MS., Hsu, LS., Chen, CJ. et al. Expression of Krűppel-like factor 5 in gastric cancer and its clinical correlation in Taiwan. Virchows Arch 459, 161–166 (2011). https://doi.org/10.1007/s00428-011-1111-0

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  • DOI: https://doi.org/10.1007/s00428-011-1111-0

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