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Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group

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Abstract

The aim of this study was to clarify whether diffuse large B-cell lymphoma (DLBCL) with a high number of epithelioid histiocytes (DLBCL-EH) could have distinctive clinicopathological characteristics. Clinicopathological findings in 22 cases with DLBCL-EH and, as a control, 96 cases with ordinary type of DLBCL were analyzed. There were ten men and 12 women with ages ranging from 38 to 91 (median, 64) years. The primary site was lymph node in 16 cases, extranodal organs in three, and unknown in three. Stage of disease was I in five cases, II in three, III in nine, and IV in five. Histologically, there was a diffuse proliferation of large lymphoid cells admixed with numerous clusters of epithelioid histiocytes sprinkling throughout the lesions. Immunohistochemically, the large lymphoid cells were CD20+, CD15−, and CD3− and positive for CD10, bcl-6, and MUM1 in nine (41%), eight (36%), and 12 (55%) of 22 cases, respectively. Epstein–Barr virus positive rate was higher in DLBCL-EH (23.8%) than that in ordinary DLBCL (4.5%; P < 0.05). Clonality analysis revealed monoclonal bands in all of the examined 20 cases with DLBCL-EH. Multivariate analysis revealed the prominent epithelioid reaction to be an independent factor for favorable prognosis. These findings suggest that DLBCL-EH could be a specific morphological variant of DLBCL associated with a better prognosis.

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Acknowledgements

The authors thank Ms. T. Sawamura, M. Sugano, K. Fujikawa, and E. Maeno for their technical assistance and Mr. Toshimitsu Hamasaki, Department of Biomedical Statistics, Osaka University, for advice on the statistical analyses. This study is supported in part by a Grant from the Ministry of Education, Culture, Sports, and Science (20014012), Japan

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoki Wada, Junichiro Ikeda, Masaharu Kohara, Eiichi Morii & Katsuyuki Aozasa

  2. Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

    Hiroyasu Ogawa

  3. Department of Clinical Haematology and Diagnostics, Graduate School of Medicine, Osaka City University, Osaka, Japan

    Masayuki Hino

  4. First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

    Shirou Fukuhara

  5. Department of Hematology, School of Medicine, Kinki University, Sayama, Osaka, Japan

    Akihisa Kanamaru

  6. Department of Functional Diagnostic Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Haruo Sugiyama

  7. Department of Hematology and Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Yuzuru Kanakura

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  1. Naoki Wada
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  2. Junichiro Ikeda
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  3. Masaharu Kohara
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  9. Yuzuru Kanakura
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  11. Katsuyuki Aozasa
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Correspondence to Katsuyuki Aozasa.

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Wada, N., Ikeda, J., Kohara, M. et al. Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group. Virchows Arch 455, 285–293 (2009). https://doi.org/10.1007/s00428-009-0827-6

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  • DOI: https://doi.org/10.1007/s00428-009-0827-6

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