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Fibroadenoma and intraduct papilloma—a common pathogenesis?

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Abstract

This report describes two cases, each showing fibroepithelial proliferation, admixed with intraduct papillomas. Case 1 was from a 13-year-old female who presented with a breast mass, while case 2 was from a 60-year-old female who also had a breast lump. Case 1 showed proliferative breast disease with multiple small papillomas, some with leaf-like contours. Broad-based parenchymal proliferations protruding into ducts were also seen, and there were overlap features between the two ends of this spectrum. Case 2, similarly, demonstrated a mixed intraductal proliferation, with papillomas on narrow stalks together with low-grade phyllode areas extending into ducts from a wider base. That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed.

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Authors and Affiliations

  1. Molecular and Cellular Pathology, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia

    Margaret C. Cummings, Leonard da Silva & Sunil R. Lakhani

  2. Royal Brisbane and Women’s Hospital, Herston, Brisbane, Queensland, 4029, Australia

    Margaret C. Cummings & Sunil R. Lakhani

  3. The School of Medicine, University of Queensland, Brisbane, Queensland, Australia

    Sunil R. Lakhani

  4. Sullivan Nicolaides Pathology, Brisbane, Queensland, Australia

    David J. Papadimos

Authors
  1. Margaret C. Cummings
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  2. Leonard da Silva
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  3. David J. Papadimos
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  4. Sunil R. Lakhani
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Corresponding author

Correspondence to Margaret C. Cummings.

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Cummings, M.C., da Silva, L., Papadimos, D.J. et al. Fibroadenoma and intraduct papilloma—a common pathogenesis?. Virchows Arch 455, 271–275 (2009). https://doi.org/10.1007/s00428-009-0817-8

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  • DOI: https://doi.org/10.1007/s00428-009-0817-8

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