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Well-differentiated and dedifferentiated liposarcomas

Virchows Archiv volume 456, pages 167–179 (2010)Cite this article

Abstract

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

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Author information

Affiliations

  1. Department of Pathology and INSERM U916, Institut Bergonié, Bordeaux, France

    Jean-Michel Coindre

  2. Laboratory of Pathology, University Victor Ségalen, Bordeaux, France

    Jean-Michel Coindre

  3. Laboratoire de Génétique Somatique des Tumeurs Solides, CHU de Nice et CNRS UMR 6543, Faculté de Médecine, Nice, France

    Florence Pédeutour

  4. Genetics and Biology of Cancers and INSERM U830, Institut Curie, Paris, France

    Alain Aurias

  5. Department of Pathology, Institut Bergonié, 229, cours de l’Argonne, 33076, Bordeaux Cédex, France

    Jean-Michel Coindre

Authors
  1. Jean-Michel Coindre
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  2. Florence Pédeutour
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  3. Alain Aurias
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Correspondence to Jean-Michel Coindre.

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Coindre, JM., Pédeutour, F. & Aurias, A. Well-differentiated and dedifferentiated liposarcomas. Virchows Arch 456, 167–179 (2010). https://doi.org/10.1007/s00428-009-0815-x

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  • DOI: https://doi.org/10.1007/s00428-009-0815-x

Keywords

  • Well-differentiated liposarcoma
  • Dedifferentiated liposarcoma
  • MDM2
  • CDK4