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Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection

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Abstract

Intraductal papillary neoplasm of bile duct (IPNB) is one of the precursor lesions of cholangiocarcinoma. Although hepatolithiasis has been extensively studied in its association with IPNBs, there had been no comprehensive study of IPNBs with Clonorchis sinensis infection. Twelve IPNBs were selected from 20 surgically resected cholangiocarcinomas, positive for C. sinensis tests (60%) and compared with eight IPNBs, selected from 51 resected cholangiocarcinomas, negative for C. sinensis tests (16%), by histologic and immunohistochemical studies of mucin core proteins and cytokeratin panels. The predominant immuno-phenotype of IPNB cases with Clonorchiasis was pancreatobiliary type (MUC1+/MUC2-/CDX2-; 9/12 cases), while that of IPNB cases with negative for C. sinensis was intestinal type (MUC1-/MUC2+/CDX2+; 6/8; p = 0.04). The prevalence of IPNBs was higher when patients with cholangiocarcinoma had Clonorchiasis. IPNBs with Clonorchiasis tended to have a more pancreatobiliary phenotype, which suggests IPNBs with Clonorchiasis may have a different tumorigenesis pathway from IPNBs with other etiologies.

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Acknowledgements

We thank Ms. Margaret Griffith for editing the manuscript.

Conflicts of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea

    Kee-Taek Jang

  2. Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Seung-Mo Hong

  3. Department of Medicine, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea

    Kyu Taek Lee & Jong Gyun Lee

  4. Department of Surgery, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea

    Seoung Ho Choi, Jin Seok Heo & Dong Wook Choi

  5. Department of Radiology and Center for Imaging Science, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, #50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea

    Dongil Choi & Jae Hoon Lim

Authors
  1. Kee-Taek Jang
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  2. Seung-Mo Hong
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  3. Kyu Taek Lee
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  4. Jong Gyun Lee
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  7. Dong Wook Choi
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  9. Jae Hoon Lim
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Corresponding author

Correspondence to Jae Hoon Lim.

Additional information

Drs. Kee-Taek Jang and Seung-Mo Hong contributed equally to this work.

This work was supported by Samsung Medical Center Clinical Research Development Program grant, # CRS-105-43-2.

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Jang, KT., Hong, SM., Lee, K.T. et al. Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection. Virchows Arch 453, 589–598 (2008). https://doi.org/10.1007/s00428-008-0682-x

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  • DOI: https://doi.org/10.1007/s00428-008-0682-x

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