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Angiogenesis in salivary carcinomas with and without myoepithelial differentiation

Virchows Archiv volume 453, Article number: 359 (2008) Cite this article

Abstract

To investigate whether salivary carcinomas with and without myoepithelial differentiation could present differences regarding degree of angiogenesis, we compared tumor vascularization between adenoid cystic (31 cases) and epithelial-myoepithelial carcinomas (14) versus mucoepidermoid (37) carcinoma. The expression of peroxiredoxin I was also studied to verify the potential relationship between cellular metabolism and microvascular density. Microvascular density for CD34 and CD105 were significantly lower in carcinomas with myoepithelial differentiation. However, no correlation was found between degree of angiogenesis and amounts of myoepithelial cells. High-grade peroxiredoxin I expression was found in 73.7% of mucoepidermoid carcinomas, whereas 85.1% of carcinomas with myoepithelial differentiation presented low-grade expression. In conclusion, carcinomas with myoepithelial differentiation, regardless of the amounts of myoepithelial cells, are associated to a significantly lower vascular density. The reasons for this lower angiogenic activity remain to be determined but could be related to metabolic characteristics of the cancer cells.

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Acknowledgements

We thank Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) for supporting this study (grant number 07/55336-2).

All experiments comply with the current laws of Brazil.

We declare that we have no conflict of interest.

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Affiliations

  1. Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil

    A. F. Costa, V. L. L. Bonfitto, J. F. L. Bonfitto, K. Metze & A. Altemani

  2. São Leopoldo Mandic Dental Research Institute, Campinas, Sao Paulo, Brazil

    A. P. D. Demasi, C. Furuse & V. C. Araújo

  3. Departamento de Anatomia Patológica, Faculdade de Ciências Médicas, UNICAMP, Rua Tessália Vieira de Camargo 126, ZIP Code 13084-971, Campinas, Sao Paulo, Brazil

    A. Altemani

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  1. A. F. Costa
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  2. A. P. D. Demasi
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  3. V. L. L. Bonfitto
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  4. J. F. L. Bonfitto
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  5. C. Furuse
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  6. V. C. Araújo
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  7. K. Metze
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  8. A. Altemani
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Correspondence to A. Altemani.

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Costa, A.F., Demasi, A.P.D., Bonfitto, V.L.L. et al. Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. Virchows Arch 453, 359 (2008). https://doi.org/10.1007/s00428-008-0664-z

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  • DOI: https://doi.org/10.1007/s00428-008-0664-z

Keywords

  • Angiogenesis
  • Adenoid cystic carcinoma
  • Mucoepidermoid carcinoma
  • Epithelial-myoepithelial carcinoma
  • Myoepithelial cell and microvessel density