Abstract
To understand the extreme complexity of biological events requires a systemic approach. This holds particularly for the disordered biological interactions that are characteristic of disease, the subject of pathology. Which options are available to untie the Gordian knot? In this contribution, the potential role of systems biology and, as a further development, systems pathology will be discussed.
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Acknowledgements
The authors would like to thank C. Denkert, Christine Sers, and W. Weichert from the Department of Pathology, Charité Berlin, as well as Prof. Dr. Gunter Kloppel and Mrs. Kay Dege and Dagmar Schmöe from the Department of Pathology, Univ.-Klinikum UK-SH Campus Kiel, for their helpful advice and discussion of the manuscript. The paper was supported by the Bundesministerium für Bildung und Forschung in connection with the project MedSys-ColoNet, Charité and Humboldt-University, Berlin.
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An erratum to this article can be found at http://dx.doi.org/10.1007/s00428-008-0718-2
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Dietel, M., Schäfer, R. Systems pathology—or how to solve the complex problem of predictive pathology. Virchows Arch 453, 309–312 (2008). https://doi.org/10.1007/s00428-008-0656-z
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DOI: https://doi.org/10.1007/s00428-008-0656-z