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Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas

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Abstract

To analyze the expression of matrix metalloproteinases (MMPs) and their relationships with the histological grades of the intraductal papillary mucinous neoplasm (IPMN) of the pancreas, we examined the frequency of expression and intracellular localization of MMP1, MMP2, MMP3, MMP7, and MMP9 in IPMN by immunohistochemistry. A total of 45 IPMN lesions (14 adenomas, 17 borderline lesions, nine noninvasive carcinomas, and five invasive lesions) from 21 patients were examined. MMP1, MMP2, MMP7, and MMP9 were expressed in tumor cells. Frequency of tumor cells expressing MMP7 was low in adenomas (median, 5.0%), higher in borderline lesions (median, 30.0%), in noninvasive carcinomas (median, 50.0%), and in invasive lesions (median, 80.0%), with a significant trend (P < 0.0001). Such a trend was also observed when the lesions were classified into gastric and intestinal subtypes (P < 0.0001 and P = 0.011, respectively). Basolateral expression of MMP7 in tumor cells was more prominent in lesions with higher histological grades (P < 0.0001). The frequency and the localization of MMP1, MMP2, and MMP9 did not correlate to the histological grades. MMP7 may contribute to the process by which IPMN advances from adenoma to carcinoma and to subsequent invasion of tumor cells in IPMN.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Urara Tamahashi, Jiro Kumagai & Yoshinobu Eishi

  2. Department of Molecular Pathophysiology, School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Touichiro Takizawa

  3. Laboratory of Pathology, Tokyo Medical and Dental University Hospital, Tokyo, Japan

    Masaki Sekine

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  1. Urara Tamahashi
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  2. Jiro Kumagai
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  3. Touichiro Takizawa
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  4. Masaki Sekine
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  5. Yoshinobu Eishi
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Correspondence to Jiro Kumagai.

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Tamahashi, U., Kumagai, J., Takizawa, T. et al. Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas. Virchows Arch 453, 79–87 (2008). https://doi.org/10.1007/s00428-008-0617-6

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  • DOI: https://doi.org/10.1007/s00428-008-0617-6

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