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Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas

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An Erratum to this article was published on 05 July 2008

Abstract

Kangai (KAI)-1 (CD82) is a metastasis suppressor gene, which belongs to the family of tetraspanin proteins. A loss of KAI-1 expression is associated with the advanced stages of many human malignancies. The present study was designed to investigate the expression pattern of KAI-1 in the normal endometrium and uterine tumors and to correlate it with the expression of tumor suppressor protein p53. KAI-1 could be found in the normal endometrium throughout the menstrual cycle. Thirteen of 42 endometrial carcinomas demonstrated moderate KAI-1 expression, but low expression of p53. Twenty-nine of 42 endometrial carcinomas showed reduced or absent KAI-1 expression, which correlated with strong expression of p53 (p < 0.001). There were significant correlations between KAI-1 expression and histological type, e.g., 93% of endometrioid carcinomas displayed a low or moderate immunostaining for KAI-1, whereas nearly all of the serous/clear cell carcinomas were KAI-1 negative (p < 0.001); tumor grading, e.g., 73% of high grade tumors showed no KAI-1 expression (p < 0.001). Most of the investigated uterine sarcomas were negative for KAI-1, whereas they displayed a strong immunostaining for p53. In conclusion, KAI-1 and p53 show inverse expression. The reduced KAI-1 expression may be the result of dysregulated p53 function and could be an important step in the endometrial carcinogenesis.

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Acknowledgements

The authors would like to thank Mr. J. Koppelmeyer for the help with the photographic work and Mrs. B. Kelp and I. Brand for the technical assistance. This work was supported in part by a grant from the Deutsche Krebshilfe foundation to AM.B. (Grant No. 107170).

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Section on Endocrinology and Metabolism of Ageing, University Clinic Hamburg-Eppendorf, Hamburg, Germany

    Juliane Briese, Christoph Bamberger & Ana-Maria Bamberger

  2. Department of Pathology and Tumor Biology, University of Leeds, St. James’s Hospital, Beckett Street, LS9 7TF, Leeds, UK

    Juliane Briese, Heinrich M. Schulte & Katja Redlin

  3. Endokrinologikum, Hamburg, Germany

    Maria Sajin

  4. Department of Morphopathology, University of Bucharest, Bucharest, Romania

    Karin Milde-Langosch

  5. Department of Gynecology, University Clinic Hamburg-Eppendorf, Hamburg, Germany

    Thomas Löning

  6. Department of Pathology, Centre for Cytology and Gynecopathology, University Clinic Hamburg-Eppendorf, Hamburg, Germany

    Juliane Briese, Heinrich M. Schulte, Maria Sajin, Christoph Bamberger, Katja Redlin, Karin Milde-Langosch, Thomas Löning & Ana-Maria Bamberger

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  1. Juliane Briese
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  2. Heinrich M. Schulte
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Correspondence to Juliane Briese.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00428-008-0625-6

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Briese, J., Schulte, H.M., Sajin, M. et al. Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas. Virchows Arch 453, 89–96 (2008). https://doi.org/10.1007/s00428-008-0608-7

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  • DOI: https://doi.org/10.1007/s00428-008-0608-7

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